gamma-glutamyl transferase


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gamma-glutamyl transferase

Gamma-glutamyl transpeptidase Lab medicine An enzyme that catalyzes the transfer of a γ-glutamyl group from glutathione or γ-glutamyl peptide to another peptide or amino acid; GGT is located on the cell membrane and microsomal fractions and is involved in amino acid transport across cell membranes; GGT is highest in the liver–GGT is the best single screening assay for detecting latent or chronic liver disease–eg, CA; in hepatobiliary diseases, a 10-fold + ↑ in GGT is seen in liver cancer, hepatic metastases, and PBC; a 4-fold + ↑ in GGT is seen in chronic active hepatitis, intrahepatic cholestasis, alcoholic hepatitis, extrahepatic biliary obstruction, and inactive cirrhosis.

gamma-glutamyl transferase

An enzyme widely distributed in body tissues and released into the blood when tissue, especially liver tissue, is damaged. Increased levels occur in liver damage from any cause. Measurements can be used as an index of alcohol abuse. Increased blood levels may sometimes occur without liver cell damage.
References in periodicals archive ?
Gamma-glutamyl transferase, reagent for determination of essential for team cobas c 501
It's called gamma-glutamyl transferase and raised levels predict stroke risk accurately.
Plasma biochemical analyte concentrations were not significantly different for calcium, amylase, uric acid, gamma-glutamyl transferase, bile acids, glucose, creatine kinase, total solids, cholesterol, triglycerides, or alkaline phosphatase levels before and after 14 days of treatment with meloxicam.
321; aspartate aminotransferase (AST): 59 U/L (5-40 U/L); alanine aminotransferase (ALT): 321 U/L (5-40 U/L); alkaline phosphatase (ALP): 154 U/L (35-125 U/L); gamma-glutamyl transferase (GGT): 168 U/L (10-45 U/L); lactate dehydrogenase (LDH): 556 U/L (200-450 U/L); blood urea nitrogen (BUN): 25 mg/dL (15-44 mg/dL); and creatinine: 0.
2 mg/L) and liver enzyme levels (aspartate aminotransferase 44 IU/L, gamma-glutamyl transferase 58 IU/L).
The liver enzyme, called gamma-glutamyl transferase (known as GGT), is a common marker of liver function and has also been associated with insulin resistance, which can be a precursor to gestational diabetes and type 2 diabetes.
Biochemistry revealed increased gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) levels.
Liver function tests showed cholestasis (total bilirubin 366 [micro]mmol/l (reference range 3 to 24 [micro]mmol/l), direct bilirubin: 250 [micro]mmol/l (reference range 2 to 7 ummol/l) with raised alkaline phosphatase of 215 unit/l (reference range 43 to 206 unit/l) and raised gamma-glutamyl transferase of 250 unit/l (reference range 3 to 60 unit/l).
Serum gamma-glutamyl transferase (GGT), an enzyme responsible for extracellular catabolism of glutathione and a marker of oxidative stress (1) has been shown to be associated with diabetes mellitus (2) and hypertension, (3) which are considered to be independent risk factors for chronic kidney disease (CKD).
Frequent occurrence of high gamma-glutamyl transferase and alanine amino transferase among Nigerian patients with type 2 diabetes.
First was the blood test which would measure levels of two enzymes - alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) - which the liver produces when it is not working properly.

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