JUP

(redirected from gamma-catenin)

JUP

A gene on chromosome 17q21 that encodes a major cytoplasmic protein common to both submembranous plaques of desmosomes and intermediate junctions. JUP forms distinct complexes with cadherins, belongs to the catenin family and contains a distinct amino acid motif known as armadillo repeat.

Molecular pathology
JUP mutations are associated with Naxos disease.
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Defining E-cadherin-associated protein complexes in epithelial cells: plakoglobin, beta- and gamma-catenin are distinct components.

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