gallbladder carcinoma

gallbladder carcinoma

a malignant neoplasm of the bile reservoir, characterized by anorexia, nausea, vomiting, weight loss, progressively worsening right upper quadrant pain, and eventually jaundice. Tumors of the gallbladder are predominantly adenocarcinomas. Often associated with biliary calculi and chronic cholecystitis, they are three to four times more common in women than in men and rarely occur before 40 years of age. Physical examination reveals an enlarged gallbladder in about half of the cases. Ultrasound or radiographic tests may aid in making a diagnosis. Complete removal of the gallbladder may sometimes be curative, but partial hepatectomy may be required because the tumor typically infiltrates the liver and ducts. Palliative surgery is often needed. Radiotherapy may be palliative. Chemotherapy is usually ineffective.
enlarge picture
Gallbladder carcinoma
References in periodicals archive ?
In a separate presentation, use of Caris Molecular Intelligence reportedly uncovered distinct targetable biomarkers in biliary tract carcinomas such as extrahepatic cholangiocarcinoma (EHCC), intrahepatic cholangiocarcinoma (IHCC), and gallbladder carcinoma (GBCA), while also suggesting the potential sensitivity of these rare, aggressive tumor types to novel and conventional therapies.
The following describes the occurrence of Streptococcus bovis bacteremia in a patient with a coexisting gallbladder carcinoma.
4) Severe dysplasia and carcinoma in situ have been found in more than 90% of patients with gallbladder carcinoma.
Primary gallbladder carcinoma is a malignant neoplasm with an incidence of 1.
Based upon the CT appearance, the differential diagnosis of adenomyomatosis versus less likely gallbladder carcinoma or chronic cholecystitis was given.
Topics include: cholecystic venous system and liver metastasis from gallbladder carcinoma, tumor angiogenesis, external palliative radiotherapy, gallbladder cancer risk in patients with a long common channel, and experimental strategies to treating biliary tract cancer, among others.
5) Gallbladder/bileducts Gallbladder carcinoma 2 (1.
1) revealed a thickened and irregularly enhancing gallbladder wall suggestive of gallbladder carcinoma and intrahepatic biliary dilation, interpreted as secondary to extension of possible tumor into the porta hepatis.
6%, 4 with stage II disease and 7 with stage IV disease) and 2 patients with gallbladder carcinoma (15.
A second presentation details the therapeutic efficacy of this compound in a mouse model of gallbladder carcinoma, which is correlated with the down regulation and translocation of erbB2, an EGFR family member.
We found that CTGF protein levels in infiltrating gallbladder carcinoma were significantly higher than in chronic cholecystitis and dysplasia.
Presenter: Shan Gao, University of Texas MD Anderson Cancer Center Monday, April 14, 2008: -- Session: Histone Deacetylase and Heat Shock Protein Inhibitors Oral presentation: Effects of histone deacetylase (HDAC) inhibitor PCI-24781 on the development of gallbladder carcinoma in BK5.