As shown in Scheme 1, an indirect esterification protocol  was adopted to synthesize the target gallates containing the benzimidazole moiety.
All the obtained gallates are white solids and exhibit good solubility in common organic solvents such as CH2Cl2, chloroform (CHCl3), tetrahydrofuran (THF), methanol, ethanol, acetone, acetonitrile, DMF and DMSO.
Similar 1H and 13C-NMR spectra in DMSO-d6 were observed for all the obtained gallates.
Synthesis, Characterization and Antimicrobial Activity of Three Gallates Containing Imidazole, Benzimidazole and Triclosan Units, Asian J.
Summary: The design of gallate and benzimidazole containing derivatives is expected to produce new bioactive molecules with multiple applications.
Thus, the obtained molecules 8 contain three bioactive units, namely, gallate, benzimidazole and phenoxymethyl, and their bioactivities can be adjusted by the type and location of substitute groups in the benzene ring of phenoxymethyl structure.
2001)  verified that the length of the alkyl chain is not a major contributor but plays an important role in eliciting the activity of the gallates.
Among the thirteen tested gallates (2-14) esterified with linear alcohols from C1 to C14, best results were observed for esters with chain lengths ranging from 9 to 12, which present C log P values of 4.
In the case of alkyl gallates, their amphiphilicity appeared to be dependent on the presence of two features: hydrophilic phenolic hydroxyls and hydrophobic alkyl chain.
When tested alone, some gallates (2-7) have not led to a significant number of epimastigotes toxicity, even at the highest concentration tested (100 [micro]M).
The interactions between compounds 1-14 and benznidazole were highly variable, indicating dependence on the gallates chain length.