galectin-3

galectin-3

A 30-kD protein, a beta-galactosidase-binding lectin encoded by LGALS3 on chromosome 14q22.3, which is thought to be involved in cell growth, adhesion, acute inflammation (neutrophil activation and adhesion, chemoattraction of macrophages, and activation of mast cells), mRNA splicing and processing, and apoptosis.

Normal expression
Mainly in the nucleus of epithelial and immune cells, neutrophils, and vascular endothelium.

Abnormal expression
Over-expression is linked to malignant transformation and metastases in carcinomas of the breast, colon, tongue, liver, and thyroid.
References in periodicals archive ?
Market availability of ARCHITECT Galectin-3 assay - In a press release issued on July 6, 2015, BG Medicine, Inc.
The major PRRs involved in fungal immune responses are C-type lectin receptors Dectin-1, DC-SIGN, Dectin-2, Mincle, Galectin-3 and Mannose Receptor.
Doctors have long recognized galectin-3 as a biomarker for degenerative disease.
And it removes excessive amounts of Galectin-3 molecules--which promote metastasis and inflammation.
In particular, it identifies MCP's different mechanisms of action against metastatic cancer, heavy metal toxicity and chronic, life threatening illnesses related to excess galectin-3," Eliaz said.
2 ( ANI ): Scientists have shown that biomarker galectin-3 can be used to assess cancer progression and inflammation.
GR-MD-02 is a complex carbohydrate drug that targets galectin-3, a critical protein in the pathogenesis of fatty liver disease and fibrosis.
Galectin-3 plays a central regulatory role in several biological and pathological disease processes.
Abbott has gained CE Marking (Conformite Europeenne) for its ARCHITECT Galectin-3 assay, a test to aid doctors in assessing the prognosis of patients diagnosed with chronic heartfailure (HF).
Galectin-3 test may help physicians identify patients at highest risk for a worse prognosis, including re-hospitalization and death, allowing them to tailor the level of care to individual patient needs[1]
Metastatic cancer, chronic inflammation, organ and tissue remodeling, and fibrosis: extensive published research reveals that these malignant conditions share an aggressive biological culprit: excess galectin-3.
The present study was focused to evaluate roles of tumor necrosis factor alpha (TNF-[alpha]) and interleukin-6 (IL-6) in Cd toxicity and their relationships with galectin-3 levels.