gain-of-function mutation


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Related to gain-of-function mutation: back mutation, genetic mutation, gene mutation, conditional mutant

gain-of-function mutation

Genetics Any mutation that results in a new activity–eg, activation of a proto-oncogene, Cf Loss-of-function mutation.

gain-of-function mutation

A change in DNA that results in the synthesis of a protein with a new or different function. Gain-of-function mutations are typically dominant.
See also: mutation
References in periodicals archive ?
In a genetic screen we identified gain-of-function mutations in a locus that codes for a CALLOSE SYNTHASE isoform CALS3.
Although JAK2 and MPL mutations are not supposed to be primary causes of MPN, but rather secondary events associated with disease progression in a still unknown way, the acquisition of one of these gain-of-function mutations seems to be necessary for the development of the myeloproliferative phenotype.
Inherited erythromelalgia is caused by gain-of-function mutations in Nav1.