In this new study, MM-398 will be administered with gadoteridol
, an MRI imaging agent to enable the real time visualization of drug distribution in the brain, through a small catheter that allows for the drug to be injected directly into the brain tumor.
Also, Group II gadolinium-based agents, such as gadoteridol
and gadobenate dimeglumine, should be used rather than Group I agents like gadodiamide and gadopentatate dimeglumine, which are associated with the greatest number of NSF cases.
Closely related diagnostic agents are gadobenate dimeglumine (MultiHance), gadodiamide (Omniscan), gadofosveset (Ablavar), gadopentetate dimeglumine (Magnevist), gadoteridol
(Prohance), and gadoversetamide (OptiMARK).
2 1) Gadoteridol
2) Gadobenate dimeglumine 3) Iomeprol 400 mg / ml 4) Iomeprol 350mg/ml Package No.
Various MR contrast agents are available on the market--gadodiamide (Omniscan), gadopentetate (Magnascan), gadoteridol
Currently, there are four gadolinium-based contrast agents available commercially in the U5: gadodiamide (Omniscan; Amersham Health), gadopentetate dimeglumine (Magnevist; Schering), gadoversetamide (OptiMARK; Mallinckrodt Medical), and gadoteridol (Prohance; Bracco).
The stability constant of gadoteridol, which is another chelate that does not affect the OCP method, is 25.
In Study A, patients also underwent an MRI before and after the administration of gadoteridol
13) A mild case of NSF has been documented following multiple exposures to gadoteridol
(ProHance, Bracco Diagnostics, Inc.
Wayne, NJ) Gadobenate dimeglumine (Gd-BOPTA) (MultiHance, Bracco Diagnostics, Princeton, NJ) Nonionic and linear Gadodiamide (Gd-DTPA-BMA) (Omniscan, GE Healthcare, Princeton, NJ) Ionic and cyclic Gadoterate meglumine (Gd-DOTA) (Dotarem/Artirem, Guerbet SA, Roissy, France) Nonionic and cyclic Gadoteridol
(Gd-HP-DO3A) (ProHance, Bracco Diagnostics) Gadobutrol (Gd-DO3A-butriol) (Gadovist, Berlex Laboratories) Table 2.