futile cycle


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fu·tile cy·cle

a cycle of phosphorylation and dephosphorylation catalyzed by two enzymes that normally function in two different metabolic pathways; the net effect is the hydrolysis of ATP and the generation of heat, for example, the futile cycle from the unregulated action of 6-phosphofructokinase and fructose-1,6-bisphosphatase in muscle; such cycles may have an important role in heat production, in the fine-tuning of the regulation of certain pathways, and may be a factor in malignant hyperthermia.
Synonym(s): substrate cycle
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References in periodicals archive ?
It would be so easy to arrest negligent parents and sweep their kids off the streets and into DSWD custody-where they would likely be released back to the parents in a futile cycle of deferred accountability and dire straits.
Ultimately, only sustained diplomacy and a change of mindset from the leaders on both sides, will end this futile cycle of violence.
The new findings hinge on a biochemical mechanism known as a futile cycle, in which cellular reactions are sped up, thereby generating more energy.
A classic example of a futile cycle would involve the reactions of fructose-6-phosphate in glycolysis and gluconeogenesis.
Sooner or later, Lebanon's rival rhetoricians need to break the futile cycle of questioning one another's honesty.
Producers will be hoping the five noms for Martin McDonagh's carnage-strewn satire of the futile cycle of violence, "The Lieutenant of Inishmore," might help the struggling Off Broadway transfer find its footing with auds.
Montville has found that "this creates a futile cycle, because eventually the cell has no more ATP to maintain its other activities--and dies.
In these long-lived worms however, there's activation of a seemingly futile cycle of breaking down fat and re-synthesizing it.
A unifying hypothesis to understand adverse events in healthcare: the Hierarchal Referral Model of Care and Clinical Futile Cycles & Please listen to me I am bleeding .