futile cycle


Also found in: Wikipedia.

fu·tile cy·cle

a cycle of phosphorylation and dephosphorylation catalyzed by two enzymes that normally function in two different metabolic pathways; the net effect is the hydrolysis of ATP and the generation of heat, for example, the futile cycle from the unregulated action of 6-phosphofructokinase and fructose-1,6-bisphosphatase in muscle; such cycles may have an important role in heat production, in the fine-tuning of the regulation of certain pathways, and may be a factor in malignant hyperthermia.
Synonym(s): substrate cycle
Mentioned in ?
References in periodicals archive ?
Ultimately, only sustained diplomacy and a change of mindset from the leaders on both sides, will end this futile cycle of violence.
The new findings hinge on a biochemical mechanism known as a futile cycle, in which cellular reactions are sped up, thereby generating more energy.
A classic example of a futile cycle would involve the reactions of fructose-6-phosphate in glycolysis and gluconeogenesis.
Sooner or later, Lebanon's rival rhetoricians need to break the futile cycle of questioning one another's honesty.
Montville has found that "this creates a futile cycle, because eventually the cell has no more ATP to maintain its other activities--and dies.
In these long-lived worms however, there's activation of a seemingly futile cycle of breaking down fat and re-synthesizing it.