fusion inhibitor


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Related to fusion inhibitor: protease inhibitor, Integrase inhibitor

fusion inhibitor

a drug that prevents sufficient joining of viral and host cell membranes for infection to occur.

fusion inhibitor

n.
Any of a class of drugs that interfere with the entry of HIV into helper T cells by inhibiting the fusion of the viral and cell membranes.
References in periodicals archive ?
Anti-HIV-1 agents known as fusion inhibitors target the N-HR or C-HR and disrupt their association, which prevents the virus from entering into the host cell.
With the FDA's recent approval of the first fusion inhibitor, correctional health care providers and pharmacists will be faced with Fuzeon, a peptide that must be administered twice a day by aseptic subcutaneous injection.
Comment: Fusion inhibitors block HIV's ability to infect healthy CD4 cells.
The third drug, called T-1249, is a fusion inhibitor that binds to the viral protein that forms a shell around HIV.
A second-generation fusion inhibitor, T-1249, is currently being evaluated in Phase I clinical studies.
announced today the completion of its third and final Phase 1 clinical study for MDT-637 with its novel inhaled antiviral fusion inhibitor, MDT-637, for the treatment of RSV infection.
MicroDose's current pipeline is anchored by MDT-637 for respiratory syncytial virus (RSV) - an inhaled, low dose, small molecule, fusion inhibitor which prevents viral replication, delivered via MicroDose's technology.
Currently he's on what's known as a "salvage" regimen that includes a boosted protease inhibitor and the injectable fusion inhibitor Fuzeon--drugs he can't give up if he hopes to keep his virus under control.
Enfuvirtide, a novel HIV-1 fusion inhibitor, had significant antiretroviral and immunologic effects when added to an otherwise optimized treatment regimen in patients with multidrug-resistant HIV-1 infection in an open-label randomized, controlled trial.
A fusion inhibitor, the compound is a 36-amino-acid peptide that will require subcutaneous injection.
announced today that it has concluded the second of two Phase I studies with its novel inhaled antiviral fusion inhibitor, MDT-637, for the treatment of RSV infection.