Investigation of the potential for mutational resistance to XF-73, Retapamulin, Mupirocin, Daptomycin, Fusidic acid
& Vancomycin in MRSA isolates during a 55 passage study.
Transconjugants were selected on brain heart infusion medium containing vancomycin (32 [micro]g/mL) and fusidic acid
Although, generally, fluoroquinolones rarely show antagonism in combination with other antibiotics, our data seem to agree with several studies in which fluoroquinolones both Grampositive and Gram-negative bacteria, in combination with ertapenem, rifampin, fusidic acid
and linezolid act antagonistically (Hosgor-Limoncu et al.
In the UK, commonly available topical antibiotics include fusidic acid
aureus strains was determined by disc diffusion method for penicillin G (10 UI), gentamicine (10 [micro]g), tobramycin (10 [micro]g), kanamycin (30 [micro]g), amikacin (30 [micro]g) erythromycin (15 [micro]g), spiramycin (10 [micro]g), lincomycin (10 [micro]g), la pristinamycin (15 [micro]g), la vancomycin (30 [micro]g), l'ofloxacin (5 [micro]g), tetracyclin (30 [micro]g), chloramphenicol (30 [micro]g), fosfomycin (50 [micro]g), fusidic acid
(10 [micro]g), la bacitracine (8 [micro]g), nalidixic acid (30 [micro]g), noviobicine (30 [micro]g) (Bioanalyse, UK) and three antimicrobials such erythromycin, tetracycline, chloramphenicol were selected and confirmed by MIC (E-test) (Biomerieux, Marcy, l'Etoile, France) on Muller Hinton agar.
Both strains were resistant to trimethoprim, co-trimoxazole, erythromycin, mupirocin (low level) and fusidic acid
TREATMENT: GPs often prescribe a fusidic acid
Treatment: GPs often prescribe a fusidic acid
cream or if badly infected, fever or swollen lymph glands, then an oral antibiotic.
Fortunately, most isolates remain sensitive to vancomycin, clindamycin and fusidic acid
Based on efficacy and resistance data, fusidic acid
is the antibiotic of choice.
26) Fusidic acid
(widely used in Europe but not available in the United States) was reportedly a very effective topical and parenteral therapy, (20,21,29) with currently reduced usefulness in Europe due to high levels of resistance from its widespread use as a monotherapy.
Postoperatively, she received intravenous flucloxacillin and oral fusidic acid
for 1 week and orally for 5 weeks.