results in very slow parasite clearance after artesunate treatment, resembling the clearance characteristics in the described case (5).
11) Babesiosis, in turn, may cause a functional asplenia
through similar mechanisms.
Revaccination with MCV4 after 5 years is recommended for individuals who continue to be at risk for infection, such as adults with anatomic or functional asplenia
Children with functional asplenia
and immune system impairment are at a risk of developing more fulminant pneumonia due to M.
In patients with the hemoglobin SS genotype, ASSC is a pediatric disease: functional asplenia
results from recurrent splenic infarctions in childhood, and by adulthood, there is little distensible splenic tissue remaining.
Vaccine is recommended for certain high-risk groups (including persons with terminal complement component deficiencies or anatomic or functional asplenia
and research or laboratory personnel at risk of exposure.
deficiencies, with anatomic or functional asplenia
On the other hand, an increased risk for pulmonary hypertension has also been found in patients with functional asplenia
or after splenectomy.
Other high-risk groups that should be vaccinated include military recruits, travelers to areas where meningococcal disease is hyperendemic or epidemic, microbiologists who are routinely exposed to isolates of Neisseria meningitidis, and people with anatomic or functional asplenia
or terminal complement deficiency.
The vaccine is still recommended for others at risk, including first-year college students, military recruits, travelers, scientists who are exposed to meningitis, patients with anatomic or functional asplenia
, and patients with terminal complement deficiency.
Medical indications: adults with anatomic or functional asplenia
or terminal complement component deficiencies.