FUT3

(redirected from fucosyltransferase 3)

FUT3

A gene on chromosome 19q13.3 that encodes a fucosyltransferase with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities, which catalyses the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. 

Molecular pathology
FUT3 mutations are responsible for most Lewis antigen-negative blood group phenotypes.
References in periodicals archive ?
6] Human genes: FUT2, fucosyltransferase 2 (secretor status included) (alias, galactoside 2-[alpha]-L-fucosyltransferase 2); FUT3, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); MGAT5, mannosyl ([alpha]-1,6-)-glycoprotein [beta]-1,6-N-acetyl-glucosaminyltransferase.