We found statistically significant correlations between increased resistance to 5-fluorocytosine and higher activity of naphthyl phosphohydrolase and lipase; increased resistance to miconazole and higher activity of beta-glucosidase; increased resistance to fluconazole and higher activity of alpha-glucosidase, alpha-galactosidase, and fucosidase.
In the case of isolates from mobile phone surfaces, we generally showed statistically significant correlations between increased resistance to 5-fluorocytosine, miconazole, fluconazole, ketoconazole, itraconazole and higher enzymatic activity of alpha-galactosidase, alpha-glucosidase, alpha-mannosidase, beta-glucuronidase, beta-glucosidase, chymotrypsin, naphthyl phosphohydrolase, fucosidase, lipase, and esterase lipase.
23) Other enzymes like mannosidase, fucosidase
, hexosaminidase and sialidase also is elevated that expose buried adhesion receptors on mucosal epithelium thus increasing the adhesion of Gram negative bacteria this foster increased adhesion and colonization by respiratory pathogens.
Forty-five minute treatment of TIMP-1 with [alpha]1-2 fucosidase
, an enzyme that hydrolyzes the [alpha]1-2 linked fucose that UEA preferentially recognizes, decreased the fluorescence signals of TIMP-1 measured by the UEA LISA at various concentrations compared to those without the treatment (see online Supplemental Fig.