freeze substitution

freeze substitution

a physiochemical process in which water frozen within cells is replaced by organic solvents at subzero temperatures; widely used as an aid for ultrastructural and immunocytochemical analysis of cells by electron microscopy.
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Bal-Tec AG's products include high-pressure and jet freezers, freeze-fracture systems, cryo transfer systems, freeze substitution systems and ion milling systems.
Leica also introduced a number of specimen preparation products, including a high pressure freezer, automatic freeze substitution systems anda new ultramicrotome.