free radical theory

free radical theory

A theory which posits that the changes seen in ageing cells and organisms are due to an accumulation of molecules damaged by free radicals. The host cell’s defences against free radical damage include glutathione peroxidase, alpha-tocopherol (vitamin E) and superoxide dismutase; intracellular superoxide levels are believed to correlate well with lifespan.
References in periodicals archive ?
The mitochondrial free radical theory of aging (MFRTA) attributes age-related decline to damaged cellular and mitochondrial DNA and RNA caused by high levels of reactive oxygen species (ROS) (e.
The free radical theory has filled a knowledge vacuum for over 50 years now, but it doesn't stand up to the evidence
THE FREE RADICAL THEORY of aging implicates chemical fragments that enter into reactions with other chemical compounds in the cell structure.
These 17 papers, including summaries, examine the latest research on the free radical theory of aging and oxidative biochemistry.
Over time, according to the free radical theory, oxidative damage accumulates in our cells and tissues, triggering many of the bodily changes that occur as we age.
According to the Free Radical Theory of Aging (FRTA), the superoxide free radical generated as a one percent by-product of normal metabolism is converted through acid-base and redox chemistry into the more active oxidizing agent hydrogen peroxide.
The free radical theory of aging is backed by more than seven decades of research on calorie restriction.
This is followed by an excellent chapter about the current theories of aging, one of which is the free radical theory of aging.
The free radical theory of prostate cancer may explain recent dietary observations.
Just watch an apple turn brown after you have sliced it; the free radical theory of aging is based on a similar mechanism of oxidation.
But more and more research points to the mitochondrial free radical theory of aging, that as people age, oxidative damage piles up in individual cells such that the energy-generation system inside some cells stops working properly.