free radical theory

free radical theory

A theory which posits that the changes seen in ageing cells and organisms are due to an accumulation of molecules damaged by free radicals. The host cell’s defences against free radical damage include glutathione peroxidase, alpha-tocopherol (vitamin E) and superoxide dismutase; intracellular superoxide levels are believed to correlate well with lifespan.
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There's a theory -- the free radical theory of aging -- that's been around for a long time that says when we oxidize our food to produce energy there's a number of free radicals that are produced that are side products of that action and many of these are quite toxic," said Beelman.
ME-3's Antioxidant Activity: In 1956, Denham Harmon, MD, introduced the Free Radical Theory of Aging in an article titled "Aging: a theory based on free radical and radiation chemistry.
in Free Radical Theory of Aging argued that free radical damage was the culprit behind aging in all living creatures.
Since the conceiving of free radical theory by Denham Harman in the 1950s people gradually realized that oxygen free radicals produced during normal respiration would cause cumulative damage which would eventually lead to organismal loss of functionality and ultimately death.
One of the most widely accepted theories proposed to explain ageing is the free radical theory, according to which oxygen-derived free radicals cause age-related impairment through oxidative damage to biomolecules, with mitochondria being the main target of free radical attack.
The free radical theory has filled a knowledge vacuum for over 50 years now, but it doesn't stand up to the evidence
1] In the free radical theory of aging, there is some imbalance between production and scavenging mechanisms of free radicals.
THE FREE RADICAL THEORY of aging implicates chemical fragments that enter into reactions with other chemical compounds in the cell structure.
These 17 papers, including summaries, examine the latest research on the free radical theory of aging and oxidative biochemistry.
Over time, according to the free radical theory, oxidative damage accumulates in our cells and tissues, triggering many of the bodily changes that occur as we age.
According to the Free Radical Theory of Aging (FRTA), the superoxide free radical generated as a one percent by-product of normal metabolism is converted through acid-base and redox chemistry into the more active oxidizing agent hydrogen peroxide.
The free radical theory of aging is backed by more than seven decades of research on calorie restriction.