free PSA

free PSA

Urology PSA in the circulation that is unbound to its usual carrier molecules, the protease inhibitors; free PSA is used to distinguish prostate CA from BPH, etc; free PSA levels are measured in Pts with a total PSA level between 4 and 10 ng/mL and nonsuspicious digital rectal examinations; ↑ free PSA indicates a ↓ risk of CA. See Prostate-specific antigen.
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In men with a normal prostate, the majority of free PSA in the serum reflects the mature protein that has been inactivated by internal proteolytic cleavage.
For estimating all the parameters, ELISA (Enzyme linked immunosorbent assay) was done with commercially available Accu Bind ELISA reagent kit for urinary free PSA (LOT EIA23KIA6H581) and Ray Biotech ELISA reagent kit for human MMP7 (Lot#: 1219140222), MMP13 (Lot#: 1219140175), TIMP1 (Lot#: 1219140191) and TIMP2 (Lot#: 1219140192).
This test analyzes how much free PSA is traveling in the blood and how much of that is bound to a companion protein.
11) Free PSA is eliminated by the kidneys, but because of their size, PSA bound to alphal-antichymotrypsin is cleared through the liver.
9--borderline at worst, and something the insurance company would have let slide--but his free PSA was lower than 10, which warranted a biopsy.
The combination of free PSA and total PSA was approved for cancer detection by the FDA in 1998 and is useful in cases with moderately elevated total PSA (4.
In this regard, all anti-PSA mAbs detected a 33 kDa protein band in human semen corresponding to free PSA.
The 4Kscore measures the blood plasma levels of four different prostate-derived kallikrein proteins - Total PSA, Free PSA, Intact PSA and Human Kallikrein-2 (hK2).