framework region

framework region

in immunology, a conserved sequence of amino acids on either side of the hypervariable regions in the variable domains of an immunoglobulin chain.

frame·work re·gion

(frām'wŏrk rē'jŭn)
immunology A conserved sequence of amino acids on either side of the hypervariable regions in the variable domains of an immunoglobulin chain.
References in periodicals archive ?
However," Blattler says, "this entails making changes in amino acids in the selected human framework region to ensure that the three-dimensional shape of the CDRs does not change so that high-affinity binding is preserved.
However," notes Blattler, "this entails making changes in amino acids in the framework region to ensure that the CDRs remain in the same conformation.
Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.
The antibody contains over 90% of human amino acid sequences, and the human framework regions are identical to epratuzumab, the Company's CD22 humanized antibody that has been studied in over 300 NHL patients.
It contains over 90% of human amino acid sequences and the human framework regions are identical to epratuzumab, the Company's CD22 humanized antibody that has been studied in over 300 NHL patients.
4917) communicates the characterization and preclinical anti-lymphoma effects of IMMU-106, the Company's new humanized antibody that targets CD20 but has framework regions of the antibody derived genetically from epratuzumab, in comparison to rituximab.

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