frameshift mutation

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read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
Except these identified SNPs, we identified five novel mutations in the FBN3 gene, including two frameshift mutations (c.
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
Frameshift mutations were consistently associated with PAH-related exposures, and these associations were strongest for PAH-DNA adducts.
TA98 is a tester strain that detects compounds that induce frameshift mutations (Maron & Ames 1983).
Except for in a few cases, missense mutations in PMP22 are believed to often lead to toxic gain-of-function and result in the CMT1 phenotype, while nonsense and frameshift mutations cause haploinsufficiency of PMP22 and result in the HNPP phenotype.
The exonic single base deletion mutations in patients FA82, FA121 and FA199 all resulted in frameshift mutations.
CEBPA mutations span the whole protein coding region, but largely fall within 2 types: N-terminal frameshift mutations that lead to truncation of the full-length p42 CEBPA protein and C-terminal in-frame mutations that affect both the full-length p42 CEBPA protein and a shorter p30 isoform that is normally coexpressed from an alternate internal start codon.
Such mutations create either missense, nonsense, or frameshift mutations, or affect consensus splice sites [reviewed in (2)].
These include frameshift mutations caused by nucleotide insertion or deletion, as well as missense, nonsense, and splice site mutations (Abramowicz et al.
For the frameshift mutations, as with the nonsense mutations, the resulting truncated mRNA transcripts would most likely be degraded by nonsense-mediated mRNA decay (19).
TA98 is a tester strain that detects compounds, which induce frameshift mutations (Maron & Ames 1983).