frameshift mutation

(redirected from frameshift mutations)
Also found in: Dictionary, Encyclopedia.

read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
Thr297Ile) Cytogenetic Patient Effect result FA82 Frameshift mutation (pathogenic) Positive FA121 Frameshift mutation (pathogenic) Positive FA189 Polymorphism (non-pathogenic) Positive FA199 Frameshift mutation (pathogenic) Not done FA312 No variation observed Not done FA402 No variation observed Unsuccessful FA465 Splice donor site mutation (pathogenic) Polymorphism (non-pathogenic) Not done Polymorphism (non-pathogenic) FA = Fanconi anaemia.
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
These results demonstrate that the "second-generation" structural analogues, idarubicin and epirubicin, also induced frameshift mutations in this assay.
These results confirmed earlier reports, which demonstrated that adriamycin induced frameshift mutations in the traditional Salmonella Mutagenicity Assay (i.
However, length variations in coding microsatellites (cMS) that produce frameshift mutations inevitably lead to truncated proteins if the respective gene is expressed.
The HFE coding region from some of these HC probands has been studied, and nine novel mutations have been described: four missense mutations (S65C, I105T, G93R, and R330M) (18-20), two frameshift mutations (V68de1T and P160de1C) (21,22), two nonsense mutations (E168X and W169X) (23), and one splice site mutation (IVS3+IG [right arrow] T) (24).
Frameshift mutations within KIT exon 11 produced PCR products with altered sizes, which were readily distinguished from wild-type KIT by CE (Fig.
16), it was concluded that the GeneChip does not detect frameshift mutations (from insertions or deletions in the p53 gene).
The chips did not detect any of the five frameshift mutations present in this study.