frameshift


Also found in: Dictionary, Encyclopedia, Wikipedia.

frame·shift

(frām'shift),
As used in genetics, a mutation that causes a sequence such that the reading frame groups of three bases in mRNA become out of register; the insertion or deletion of one or two bases, for example, would lead to an altered grouping of three bases causing incorrect amino acid residues to be incorporated into growing polypeptide chains, or would signal premature chain termination.
Frameshiftclick for a larger image
Fig. 165 Frameshift . The effect of inserting an extra DNA base into nucleotide base sequence.

frameshift

an altered reading of the GENETIC CODE during TRANSLATION in PROTEIN SYNTHESIS, caused by a change in the nucleotide base sequence of DNA and RNA due to the insertion or deletion of one or more bases (except three bases or multiples of three bases). Fig. 165 shows an example of a DNA base insertion between bases 4' and 5'. When the sequence is read from left to right the first amino acid is unchanged, but the second and subsequent amino acids will be altered, producing a mutant protein.
References in periodicals archive ?
TA98 is a tester strain that detects compounds, which induce frameshift mutations (Maron & Ames 1983).
Nonsense and frameshift mutations account for up to 48% and 32% of all small lesions in DMD patients, while nonsense and frameshift mutations represent only 24% and 16% of them in BMD patients, respectively.
Thr297Ile) Cytogenetic Patient Effect result FA82 Frameshift mutation (pathogenic) Positive FA121 Frameshift mutation (pathogenic) Positive FA189 Polymorphism (non-pathogenic) Positive FA199 Frameshift mutation (pathogenic) Not done FA312 No variation observed Not done FA402 No variation observed Unsuccessful FA465 Splice donor site mutation (pathogenic) Polymorphism (non-pathogenic) Not done Polymorphism (non-pathogenic) FA = Fanconi anaemia.
Two new frameshift mutations in exon 25 of FBN3 were also identified.
Except for in a few cases, missense mutations in PMP22 are believed to often lead to toxic gain-of-function and result in the CMT1 phenotype, while nonsense and frameshift mutations cause haploinsufficiency of PMP22 and result in the HNPP phenotype.
2012_2020duplCAGC 17 1 (black) Pathogenic; frameshift duplication c.
One possible explanation for the largest odds ratio occurring for Leu1007fsinsC is that Leu1007fsinsC is a frameshift variation followed by a premature stop codon that truncates the protein by 33 amino acid residues, whereas the other 2 variants have less detrimental effects on the protein.
Amplification with PCR and sequencing was used to identify the binary toxin gene (cdtB) and an 18-bp deletion and a frameshift mutation at position 117 in the tcdC gene.
These include frameshift mutations caused by nucleotide insertion or deletion, as well as missense, nonsense, and splice site mutations (Abramowicz et al.
The mutation was predicted to cause the 96[sup]th amino acid of the GATA3, tryptophan, to be substituted by glycine, resulting in a frameshift (p.
SIRF 17 will launch on the evening of Thursday, August 3, with aerial theatre show, Frameshift.