frameshift


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frame·shift

(frām'shift),
As used in genetics, a mutation that causes a sequence such that the reading frame groups of three bases in mRNA become out of register; the insertion or deletion of one or two bases, for example, would lead to an altered grouping of three bases causing incorrect amino acid residues to be incorporated into growing polypeptide chains, or would signal premature chain termination.
Frameshiftclick for a larger image
Fig. 165 Frameshift . The effect of inserting an extra DNA base into nucleotide base sequence.

frameshift

an altered reading of the GENETIC CODE during TRANSLATION in PROTEIN SYNTHESIS, caused by a change in the nucleotide base sequence of DNA and RNA due to the insertion or deletion of one or more bases (except three bases or multiples of three bases). Fig. 165 shows an example of a DNA base insertion between bases 4' and 5'. When the sequence is read from left to right the first amino acid is unchanged, but the second and subsequent amino acids will be altered, producing a mutant protein.
References in periodicals archive ?
The bi-directional dideoxy sequencing of 20 receptor kinase domains and their adjacent regions revealed novel somatic mutations in fibroblast growth receptor 1 (FGFR1) and frameshift mutations in growth factor receptor alpha (PDFGRA).
Certain truncating mutations, especially frameshift mutations, appear to be linked to development of renal cancer, which was far more common in females than in males in the MCUL study.
Among the biological/anatomical traits identified by this approach are bipedalism, cranial capacity, dentition, an opposable thumb, a lowered larynx, a developed Broca's area of the brain, the presence of a frameshift mutation in the MYH 16 (myosin heavy chain type 16) gene, and the structure of the ASPM (abnormal spindle-like microcephaly) associated gene.
7) Mutations so far described in Tarui's disease are the common point mutation of the exon/intron 5 junction, (8,9) a cryptic splice site mutation within exon 15, (10) a 75-bp inframe deletion at the splice donor site of intron 5, (10) a nonsense mutation associated with retention of intron 10, (11) a single base deletion in exon 22, resulting in a frameshift mutation and premature stop codon, (10) a deletion of the 2003 C nucleotide, (12) a G1127A frameshift resulting in a 155nt retention of intron 13, (5) and an A-G change in intron 16.
This study shows that using the Salmonella Mutagenicity Assay that idarubicin, like daunomycin, can induce frameshift (TA98; 16.
61) This test will detect missense mutations (single nucleotide alterations that change an amino acid), and most frameshift or nonsense mutations that result in protein truncation.
The FrameShift Pro - iPad stand constructed of aluminum featuring a hand brushed finish, military grade abrasion resistant rubber padding and stainless steel hardware
A form of albinism in cattle is caused by a tyrosinase frameshift mutation.
The exonic single base deletion mutations in patients FA82, FA121 and FA199 all resulted in frameshift mutations.
This new Hi-Q(TM) chemistry demonstrates that the Ion Torrent platform can reliably detect difficult frameshift mutations.
6% (69 of 70; Table 5) and demonstrated an ability to correctly identify different classes of mutations, including nonsense, missense, frameshift, in-frame deletion, splice site, and large-deletion mutations (Table 1).
sonnei (Ss046) it is inactivated by a frameshift mutation and an insertion sequence, respectively (12).