frame-shift mutation


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Related to frame-shift mutation: point mutation, missense mutation

frame-shift mutation

A genetic mutation caused by the addition or deletion of a number of NUCLEOTIDES other than three. Because the genetic code consists of codons (groups of three nucleotides), such a change shifts the reading frame for translation so all adjacent codons are changed and a completely new set is read into the messenger ribonucleic acid (mRNA).
References in periodicals archive ?
By sequencing the polymerase chain reaction fragments of the entire coding region and the exon-intron boundaries of TSC1 and TSC2, we detected a novel frame-shift mutation (c.
Severe lactic acidosis caused by a novel frame-shift mutation in mitochondrial-encoded cytochrome c oxidase subunit II.
It leads to the formation of a frame-shift mutation and causes a premature stop codon at amino acid 102 (16, 17).
We predicted that 2 historical isolates would have nonfunctional tox genes, with single nucleotide deletions at positions 55 and 226 in fragment A, causing frame-shift mutations and premature stop codons at aa 38 and aa 92, respectively.