frame-shift mutation


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Related to frame-shift mutation: point mutation, missense mutation

frame-shift mutation

A genetic mutation caused by the addition or deletion of a number of NUCLEOTIDES other than three. Because the genetic code consists of codons (groups of three nucleotides), such a change shifts the reading frame for translation so all adjacent codons are changed and a completely new set is read into the messenger ribonucleic acid (mRNA).
References in periodicals archive ?
Over the past decades several cases of genetic polymorphisms, described in peer-reviewed papers and listed in the analbuminemia register (2), have been characterized as representing site-specific mutations, splice-site mutations, or frame-shift mutations.
Coexpression of substantially different wild-type and mutant peptides, because of nonsense or frame-shift mutations, produced more variable ratios of expression judged by either criterion.