fragility test


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fra·gil·i·ty test

a test that measures the resistance of erythrocytes to hemolysis in hypotonic saline solutions; erythrocytes to be tested are added to varying concentrations of saline (usually ranging from 0.85-0.10% sodium chloride with 0.05% increments), and beginning and complete hemolysis are measured; normal erythrocytes show initial hemolysis at concentrations of 0.45-0.39% and complete hemolysis at 0.33-0.30%; in hereditary spherocytosis, the fragility of the erythrocytes is markedly increased, whereas in thalassemia, sickle cell anemia, and obstructive jaundice the fragility of the erythrocytes is usually reduced.

fragility test

(1) Capillary fragility test, see there.  
(2) Osmotic fragility test, see there.

fra·gil·i·ty test

(fră-jil'i-tē test)
A measurement of the resistance of erythrocytes to hemolysis in hypotonic saline solutions; erythrocytes to be tested are added to varying concentrations of saline and beginning and complete hemolysis are measured; in hereditary spherocytosis, the fragility of the erythrocytes is markedly increased, whereas in thalassemia and sickle cell anemia, the fragility of the erythrocytes is usually reduced.
References in periodicals archive ?
One Tube Osmotic Fragility Test (OF): The "Thal screen solution" was obtained from Chiang Mai University.
We are seeking information regarding the feasibility and cost effectiveness of performing the osmotic fragility test, which is so labor intensive.
If these laboratory tests are suggestive and there is a family history of anemia, you still may wish to perform a definitive osmotic fragility test.