osmotic fragility

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fragility

 [frah-jil´ĭ-te]
susceptibility, or lack of resistance, to influences capable of causing disruption of continuity or integrity.
fragility of blood erythrocyte fragility.
capillary fragility abnormal susceptibility of capillary walls to rupture with extravasation.
erythrocyte fragility unusual susceptibility of erythrocytes to hemolysis under certain conditions; see mechanical fragility and osmotic fragility.
mechanical fragility unusual susceptibility of certain erythrocytes to hemolysis under mechanical stress.
osmotic fragility susceptibility of certain erythrocytes to hemolysis when exposed to increasingly hypotonic solutions; seen in some forms of hemolytic anemia and spherocytosis. A test of osmotic fragility is used in diagnosis of some types of hemolytic anemia.

os·mot·ic fra·gil·i·ty

the susceptibility of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions.

osmotic fragility

an assay in which whole blood is pipetted to each of a series of saline solutions of graduated concentration. The series begins with water and increases in concentration to normal (0.85%) saline. The osmotic fragility test is used to detect spherocytosis because spherocytes rupture (lyse) in saline concentrations near the normal level. The assay also detects target cells, which, owing to their reduced hemoglobin content, are able to withstand osmotic stress and rupture only at very dilute saline concentrations. Also called erythrocyte fragility.

osmotic fragility

Red blood cell osmotic fragility test Hematology The susceptibility of RBCs to osmotic lysis; in hypotonic solutions, RBCs behave as perfect osmometers, where the free water rapidly equilibrates, causing the RBCs to swell. See Hereditary spherocytosis.

os·mot·ic fra·gil·i·ty

(oz-mot'ik fră-jil'i-tē)
The susceptibility of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions.
Synonym(s): fragility of the blood.

osmotic

emanating from or pertaining to the pressure of osmosis.

osmotic concentration
concentration of osmotically active particles in solutions.
osmotic fragility
the susceptibility of red blood cells to hemolyze in hypotonic saline solutions; may be used as a test of red cell fragility when a series of increasing concentrations is used. See also erythrocyte fragility.