fractional shortening


Also found in: Acronyms.

fractional shortening

The reduction of the length of the end-diastolic diameter that occurs by the end of systole. Like the ejection fraction, this is a measure of the heart's muscular contractility. If the diameter fails to shorten by at least 28%, the efficiency of the heart in ejecting blood is impaired.
References in periodicals archive ?
Achieved data are occupied in formula and by this mean fractional shortening are calculated.
Current study is present one of the most important usages of echocardiography and fractional shortening index in dogs and effect of exercise on this index.
This presentation concluded that the cardiac myosin activator, CK-0689705, increases the fractional shortening in ventricular myocytes in a dose-dependent manner, does not increase the calcium transient and increases contractility in ventricular myocytes from rats with defined heart failure.
The data presented today show that this mechanism generated a dose-dependent increase in fractional shortening in ventricular myocytes, a measure of cardiac contractility.
At the same dose, CK- 1827452 also produced a mean increase in fractional shortening of 9.
25 mg/kg/hr, CK-1827452 increased fractional shortening (42%), stroke volume (45%) and cardiac output (32%) without increasing myocardial oxygen consumption.
Doses that exceeded the MTD of CK-1827452 were associated with longer prolongations of systolic ejection time and larger increases in ejection fraction and fractional shortening than those that were observed with doses at or below the MTD.
At this dose, the six-hour infusion of CK-1827452 produced a statistically significant and clinically relevant increase in ejection fraction and fractional shortening as measured from baseline to the end of the infusion in comparison to placebo; these clinically relevant increases in cardiac function were associated with a statistically significant prolongation of systolic ejection time.
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