HF--heart failure, LVEF--left ventricular ejection fraction, LVFS--left ventricular fractional shortening
, NT-proBNP--N terminal-probrain natriuretic peptide, TNF-[alpha]--tumor necrosis factor-alpha Table 2.
Achieved data are occupied in formula and by this mean fractional shortening are calculated.
Current study is present one of the most important usages of echocardiography and fractional shortening index in dogs and effect of exercise on this index.
Additionally, endocardial fractional shortening
, which measures circumferential function, is strictly influenced by left ventricle geometry and radial thickening.
In addition, fractional shortening
was significantly improved (p<0.
This presentation concluded that the cardiac myosin activator, CK-0689705, increases the fractional shortening
in ventricular myocytes in a dose-dependent manner, does not increase the calcium transient and increases contractility in ventricular myocytes from rats with defined heart failure.
Transcatheter closure of the coronary fistula relieved symptoms of congestive heart failure gradually and improved fractional shortening
(24%) and ejection fraction (46%).
The data presented today show that this mechanism generated a dose-dependent increase in fractional shortening
in ventricular myocytes, a measure of cardiac contractility.
At the same dose, CK- 1827452 also produced a mean increase in fractional shortening
25 mg/kg/hr, CK-1827452 increased fractional shortening
(42%), stroke volume (45%) and cardiac output (32%) without increasing myocardial oxygen consumption.
Doses that exceeded the MTD of CK-1827452 were associated with longer prolongations of systolic ejection time and larger increases in ejection fraction and fractional shortening
than those that were observed with doses at or below the MTD.
At this dose, the six-hour infusion of CK-1827452 produced a statistically significant and clinically relevant increase in ejection fraction and fractional shortening
as measured from baseline to the end of the infusion in comparison to placebo; these clinically relevant increases in cardiac function were associated with a statistically significant prolongation of systolic ejection time.