More recently, the study team tried PSA-targeted fowlpox
and vaccinia vaccines in combination with costimulatory molecules in 15 men with metastatic prostate cancer.
In recent years, fowlpox
outbreaks in poultry flocks have been gradually increasing because of an emerging novel type of FWPV (3-5).
ECOG 7897 is an ongoing Phase II clinical trial for the evaluation of a prime/boost vaccine strategy using vaccinia virus and fowlpox
virus expressing human PSA in patients with hormone-dependent prostate cancer.
vaccines coexpressing HA of subtype H5N1 and chicken IL-18 have been shown to induce complete protection in vaccinated chickens (19).
Although the etiology of the carcinoma in this case may have been secondary to chronic focal trauma, the possibility of a latent or chronic form of fowlpox
should be considered in the pathogenesis of the lesion
vaccines that express the hemagglutinin protein of the field virus have also been reported to be efficacious for reducing shedding levels and providing clinical protection (14).
Although domestic poultry had long been assumed to be the most likely source of the virus in Hawaii, the 2 or more genetically distinct variants of the virus circulating in native forest birds are distinct from fowlpox
and have strong similarities to canarypox.
Efficacy of nucleoprotein and haemagglutinin antigens expressed in fowlpox
virus as vaccine for influenza in chickens.
Therion's vaccines are administered via subcutaneous injection in a "prime-boost" fashion, employing vaccinia as the priming vector, followed by sequential doses with a fowlpox
We describe here a simple polymerase chain reaction-based method for identification and discrimination of avipoxvirus strains similar to the fowlpox
or canarypox viruses.
This clinical experience has yielded an optimized vaccine configuration that comprises recombinant vaccinia and fowlpox
viruses that simultaneously express TRICOM with a target antigen, administered sequentially in a prime-boost regimen which uses vaccinia to stimulate an initial immune response, followed by multiple immunizations with fowlpox
, to sustain the response.
Therion Biologics' PSA-based PROSTVAC vaccines, vaccinia and fowlpox
, were used in a "prime-boost" protocol in stage D0 prostate cancer patients, who have rising PSA levels but no evidence of metastases.