fourth-generation cephalosporin


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fourth-generation cephalosporin

a broad-spectrum cephalosporin having the greatest activity against gram-negative organisms of any of the cephalosporins. Cefepime is often so classified, although it is sometimes included with the third-generation cephalosporins.

fourth-generation cephalosporin

Any of a group of cephalosporin antibiotics possessing broad-spectrum activity They are zwitterions that can penetrate the outer membranes of gram-negative bacteria. Many can cross the blood-brain barrier and are used to treat meningitis.
See also: cephalosporin
References in periodicals archive ?
The cefepime MIC is useful for predicting the presence of CTX-M enzymes, which usually confer resistance to this fourth-generation cephalosporin.
The drug, cefquinome, is a fourth-generation cephalosporin, which is part of a class of drugs highly valued in human medicine as treatment for serious and life-threatening infections.
Dura's Acute Care Division is addressing the need for new choices in the treatment of acute, severe infections with its flagship hospital antibiotic Maxipime, the first and only fourth-generation cephalosporin approved in the United States.