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fourth-generation cephalosporin

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fourth-generation cephalosporin,
a broad-spectrum cephalosporin having the greatest activity against gram-negative organisms of any of the cephalosporins. Cefepime is often so classified, although it is sometimes included with the third-generation cephalosporins.


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Currently in the United States, no fourth-generation cephalosporins are okayed for use among animals raised for human consumption.
Third-generation cephalosporins, such as cefotaxime [Claforan], ceftriaxone [Rocephin], cefoperazone [Cefobid], ceftazidime [Fortaz, and others], or ceftizoxime [Cefizox], and fourth-generation cephalosporins such as cefepime [Maxipime] should not be used for routine surgical prophylaxis because they are expensive, some are less active than cefazolin against staphylococci, and their spectrum of activity includes organisms rarely encountered in elective surgery," Dr.
a fourth-generation cephalosporin antibiotic; used as the hydrochloride salt.
 
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