founder cell

founder cell

A cell capable of contributing to the establishment of one or more cell populations but is not a stem cell.
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Alan showed increased cancer founder cell survival, compromised cell death responses and altered mutation incidence in mice with mutant p53 and mismatch repair pathways.
He pursued the hypothesis that p53 normally drives the death of cells bearing DNA damage and that when p53 is non-functional these cells persist with the potential to become the founder cells of tumours.
Classical experiments performed on gastropod embryos demonstrate that the D macromere plays a critical role in axial patterning as the founder cell of the dorsal lineage.
In addition, cell transplantation studies have indicated that the segmental founder cells of the leech ('primary blast cells') already possess an intrinsic segment identity several days prior to the onset of Hox gene expression, and will express that original identity - including segment-specific Hox expression - even if their descendant clones are forced to develop in inappropriate segments (9, 11).
A sea urchin homologue of the chordate Brachyury (T) gene is expressed in the secondary mesenchyme founder cells.