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fosphenytoin |
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fosphenytoin /fos·phen·y·to·in/ (fos´fen-ĭ-toin″) a prodrug of phenytoin used as the sodium salt in the treatment of epilepsy, excluding petit mal epilepsy.
fosphenytoin, an anticonvulsant. indications It is used to treat generalized tonic-clonic seizures and status epilepticus. contraindications Factors that prohibit its use include known hypersensitivity to this drug, psychiatric conditions, pregnancy, bradycardia, sinoatrial and atrioventricular block, and Stokes-Adams syndrome. adverse effects Life-threatening effects are ventricular fibrillation, nephritis, agranulocytosis, leukopenia, aplastic anemia, thrombocytopenia, megaloblastic anemia, and Stevens-Johnson syndrome. Other adverse effects include drowsiness, dizziness, insomnia, paresthesias, depression, suicidal tendencies, aggression, headache, confusion, hypotension, nystagmus, diplopia, blurred vision, nausea, vomiting, constipation, anorexia, weight loss, hepatitis, jaundice, gingival hyperplasia, urine discoloration, rash, lupus erythematosus, hirsutism, and hypocalcemia. fosphenytoin [fos´fen-ĭ-toin″] a prodrug of phenytoin used as the sodium salt in treatment of epilepsy, excluding the petit mal type; administered intravenously or intramuscularly.
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amethopterin antimetabolite Blenoxane bleomycin sulfate Cerebyx etonogestrel and ethinyl estradiol vaginal ring fosphenytoin sodium ifosfamide methotrexate methotrexate sodium MTX norelgestromin/ethinyl estradiol status epilepticus Tindamax tinidazole | Vitamin D Depletion by Drugs The following drugs deplete vitamin D: barbiturates, carbamazepine, cholestyramine, cimetidine, colestipol, corticosteroids, famotidine, fosphenytoin, isoniazid, mineral oil, nizatidine, phenobarbital, phenytoin, ranitidine, and rifampin. These medications include phenobarbital, primidone (Mysoline), phenytoin (Dilantin), carbamazepine (Tegretol), fosphenytoin (Cerebyx), and valproic acid (Depakote). The Joint Venture has now placed purchase orders for five Injectable ANDA products, one for Fosphenytoin Sodium, two for Ondansetron, one for Flumazenil and one for an expected ANDA approval in the near term. |
fosphenytoin |
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