fosphenytoin


Also found in: Dictionary, Wikipedia.
Related to fosphenytoin: Fosphenytoin sodium

fosphenytoin

 [fos´fen-ĭ-toin″]
a prodrug of phenytoin used as the sodium salt in treatment of epilepsy, excluding the petit mal type; administered intravenously or intramuscularly.

fosphenytoin

/fos·phen·y·to·in/ (fos´fen-ĭ-toin″) a prodrug of phenytoin used as the sodium salt in the treatment of epilepsy, excluding petit mal epilepsy.

fosphenytoin

(fŏs′fĕn′ĭ-tō′ĭn, -fə-nĭt′ō-)
n.
A prodrug that is metabolized to phenytoin and administered parenterally for the treatment of seizures.

fosphenytoin

an anticonvulsant.
indications It is used to treat generalized tonic-clonic seizures and status epilepticus.
contraindications Factors that prohibit its use include known hypersensitivity to this drug, psychiatric conditions, pregnancy, bradycardia, sinoatrial and atrioventricular block, and Stokes-Adams syndrome.
adverse effects Life-threatening effects are ventricular fibrillation, nephritis, agranulocytosis, leukopenia, aplastic anemia, thrombocytopenia, megaloblastic anemia, and Stevens-Johnson syndrome. Other adverse effects include drowsiness, dizziness, insomnia, paresthesias, depression, suicidal tendencies, aggression, headache, confusion, hypotension, nystagmus, diplopia, blurred vision, nausea, vomiting, constipation, anorexia, weight loss, hepatitis, jaundice, gingival hyperplasia, urine discoloration, rash, lupus erythematosus, hirsutism, and hypocalcemia.

fosphenytoin

Cerebyx® Neurology A prodrug of phenytoin, which is pharmacologically equivalent to, but causes less phlebitis, soft tissue damage. See Phenytoin, Seizure. Cf Status spilepticus.
References in periodicals archive ?
Phosphate monoesters, such as fosphenytoin, are not the only group of prodrugs that contain a reactive site that could be chemically modified.
The elimination half-lives of any possible cross-reacting substances were estimated in subjects 1, 3, and 5 after the discontinuation of fosphenytoin administration by plotting log[DELTA] vs time.
However, because the potential risks associated with phenytoin and fosphenytoin still are being investigated, "there is not yet enough information to recommend testing" for the allele.
Fosphenytoin is a phosphate ester prodrug of phenytoin with an improved solubility and better tolerance after intramuscular or intravenous administration.
Venous irritation related to intravenous administration of phenytoin versus fosphenytoin.
Fosphenytoin (Cerebyx[R], Parke-Davis) is a recently approved, freely water-soluble phosphate ester prodrug of phenytoin that delivers phenytoin into the systemic circulation with ~100% bioavailability, after IM or IV administration.
Akorn-Strides, LLC today announced the approval of an ANDA for Fosphenytoin Sodium Injection USP, 100 mg/2mL and 500 mg/10mL (equivalent to Phenytoin Sodium).
Fosphenytoin (Cerebyx[R]) was approved by the FDA in 1995 as an injectable formulation of phenytoin (Dilantin[R]).
Obtain samples after intravenous dosing of phenytoin at 1-4 h postdose or at 2 h postintravenous or 4 h postintramuscular dosing with fosphenytoin.
These approvals were for Caffeine Citrate injection, USP, 20 mg/mL, the generic equivalent of Cafcit([R]) Injection, Oxytocin Injection, USP, 30 mL, the generic equivalent of Pitocin([R]) and Fosphenytoin Sodium Injection, 100 mg, 2 mL and 500 mg, 10 mL vials, USP, the generic equivalent of Cerebyx([R]).
Barbiturates, which may be used for coma induction (pentobarbital) and antiepileptic drugs (phenobarbital, phenytoin, fosphenytoin and carbamazepine) may all increase steroid degradation, necessitating as much as double the original dose.
Fosphenytoin itself has no pharmacological activity but is dephosphorylated in vivo by phosphorylases to the active drug, phenytoin.