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Related to fosphenytoin: Fosphenytoin sodium
fosphenytoin/fos·phen·y·to·in/ (fos´fen-ĭ-toin″) a prodrug of phenytoin used as the sodium salt in the treatment of epilepsy, excluding petit mal epilepsy.
A prodrug that is metabolized to phenytoin and administered parenterally for the treatment of seizures.
indications It is used to treat generalized tonic-clonic seizures and status epilepticus.
contraindications Factors that prohibit its use include known hypersensitivity to this drug, psychiatric conditions, pregnancy, bradycardia, sinoatrial and atrioventricular block, and Stokes-Adams syndrome.
adverse effects Life-threatening effects are ventricular fibrillation, nephritis, agranulocytosis, leukopenia, aplastic anemia, thrombocytopenia, megaloblastic anemia, and Stevens-Johnson syndrome. Other adverse effects include drowsiness, dizziness, insomnia, paresthesias, depression, suicidal tendencies, aggression, headache, confusion, hypotension, nystagmus, diplopia, blurred vision, nausea, vomiting, constipation, anorexia, weight loss, hepatitis, jaundice, gingival hyperplasia, urine discoloration, rash, lupus erythematosus, hirsutism, and hypocalcemia.