fosfomycin


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antibacterial

 [an″te-, an″ti-bak-tēr´e-al]
1. destroying or suppressing the growth or reproduction of bacteria.
2. an agent having such properties.

fosfomycin

/fos·fo·my·cin/ (fos-fo-mi´sin) an antibacterial agent active against a wide range of gram-positive and gram-negative bacteria, used in the treatment of urinary tract infection; administered orally as the tromethamine salt.

fosfomycin

a urinary antiinfective.
indications It is used to treat infections of the urinary tract caused by Enterococcus faecalis and Escherichia coli.
contraindications Known hypersensitivity to this drug prohibits its use.
adverse effects Adverse effects include vaginitis, dysuria, hematuria, menstrual disorder, fever, insomnia, somnolence, migraine, asthenia, nervousness, constipation, dry mouth, flatulence, increased SGPT, dyspepsia, and pruritus. Common side effects are headache, dizziness, nausea, vomiting, anorexia, diarrhea, and rash.

fosfomycin

a phosphonic acid compound with antibacterial activity.
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References in periodicals archive ?
Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: Randomized controlled trial.
In vitro susceptibility results revealed that all the 171 (100%) CPE isolates susceptible to PolymyxinB, while susceptibility against Fosfomycin and Tigecycline was 132 (77%) and 49 (29%) respectively.
Antibiotics such as linezolid, tigecycline, rifampicin, fosfomycin and fusidic acid have been proved effective for MRSA infections internationally, but there is limited data regarding their efficacy in local clinical isolates.
We tested 890 vancomycin-resistant enterococcal isolates by growth on Mueller-Hinton agar plates containing 100 or 200 [micro]g/mL fosfomycin and 25 [micro]g/mL glucose-6-phosphate (Sigma-Aldrich, St.
TABLE 3 Antibiotics for the acute treatment of recurrent urinary tract infection (24) Antibiotic Dose Frequency Duration Cure (days) rate (%) Trimethoprim- 160 mg/ Twice daily 3 93 sulfamethoxazole 800 mg Nitrofurantoin 100 mg Twice daily 5-7 93 Fosfomycin 3g Single dose 1 91 Beta-lactams * Varies Varies by drug 3-5 89 by drug Fluoroquinolones * Varies Varies by drug 3 90 by drug * The US Food and Drug Administration recommends using only when no other treatment options exist.
There were intermittent zones of inhibition to the claforan, nalidixic acid, amoxycillin, fosfomycin, fortum, and erythromycin (Table 3).
Because of having a very low resistance ratio, fosfomycin is one of the most appropriate agents for treating uncomplicated cystitis (23).
Previously treated with nitrofurantoin and fosfomycin 7 * 68, F Johannesburg Admitted for hip replacement, diabetic 8 * 36, F Pretoria Previous hospitalisation (>6 months) for renal transplant 9 * 19, F Cape Town No prior antibiotics M = male; F = female; NR = not recorded; PCR = polymerase chain reaction; ICU = intensive care unit; MIC = minimum inhibitory concentration; TB = tuberculosis; UTIs = urinary tract infections.
Oral antibiotics such as trimethoprim/sulfamethoxazole, nitrofurantoin or fosfomycin are typically first line antibiotics.
Women aged 18-65 years were randomized to a single dose of the broad-spectrum antibiotic fosfomycin 3 g (n = 246) or ibuprofen three 400-mg doses (n = 248) for 3 days.