FOSL1

(redirected from fos-related antigen 1)

FOSL1

A gene on chromosome 11q13 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.
References in periodicals archive ?
For example, Fudala and colleagues (21) found that nuclear factor-[kappa]B and Fos-related antigen 1 (a member of the activator protein 1 family) are elevated in ARDS lung tissue, suggesting that continued examination of how proinflammatory signaling involving nuclear factor-[kappa]B initiates epithelial cell dysfunction and apoptosis, including inflammatory cascade molecules--cytokines and adhesion molecules--could be beneficial.
Increased levels of nuclear factor kB and Fos-related antigen 1 in lung tissues from patients with acute respiratory distress syndrome.