formoterol fumarate


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Related to formoterol fumarate: budesonide, Salmeterol

formoterol fumarate

Atimos Modulite (UK), Foradil (UK), Foradil Aerolizer, Oxeze (CA), Oxis (UK), Perforomist

Pharmacologic class: Sympathomimetic; long-acting, selective beta2-adrenergic receptor agonist

Therapeutic class: Bronchodilator

Pregnancy risk category C

Action

Stimulates intracellular adenylate cyclase, relaxing bronchial smooth muscle and inhibiting release of mediators of immediate hypersensitivity

Availability

Capsules for oral inhalation (used with Aerolizer inhaler): 12 mcg

Indications and dosages

Long-term maintenance of asthma; prevention or long-term maintenance of bronchospasm in patients with chronic obstructive pulmonary disease

Adults and children ages 5 and older: Contents of 1 capsule inhaled orally via Aerolizer q 12 hours

Acute prevention of exercise-induced bronchospasm (on occasional, as-needed basis)

Adults and children ages 5 and older: Contents of 1 capsule inhaled orally via Aerolizer at least 15 minutes before start of exercise. Wait 12 hours after initial dose before giving repeat dose.

Contraindications

• Hypersensitivity to drug or its components
• Tachyarrhythmias

Precautions

Use cautiously in:
• acute asthma symptoms, deteriorating asthma, cardiovascular disorders, seizure disorders, thyrotoxicosis, diabetes, possible hypokalemia
• patients older than age 75
• labor
• pregnant or breastfeeding patients
• children younger than age 5.

Administration

• Be aware that drug is not intended for acute asthma attacks.
• Use capsules only with Aerolizer inhaler supplied.
• Keep capsules in blister until immediately before use.

Make sure patient doesn't swallow capsules.

Adverse reactions

CNS: tremor, dizziness, insomnia, anxiety

CV: chest pain

EENT: sinusitis, pharyngitis, tonsillitis

GI: dry mouth

Metabolic: hypokalemia, hyperglycemia

Musculoskeletal: muscle cramps, back pain, leg cramps

Respiratory: bronchitis, chest infection, dyspnea, upper respiratory tract infection, increased sputum

Skin: pruritus, rash

Other: dysphonia, viral infection, fever

Interactions

Drug-drug.Adrenergics: potentiation of formoterol's sympathomimetic effects

Beta-adrenergic blockers: partial or total inhibition of formoterol's effects

Cardiac glycosides, methylxanthines, potassium-wasting diuretics, steroids: potentiation of formoterol's hypokalemic effects, increased risk of arrhythmias

Disopyramide, MAO inhibitors, quinidine, phenothiazines, procainamide, tricyclic antidepressants: prolonged QTc interval, increased risk of ventricular arrhythmias

Halogenated hydrocarbon anesthetics: increased risk of arrhythmias

Levodopa, levothyroxine, oxytocin: impaired cardiac tolerance of formoterol

Drug-diagnostic tests.Blood glucose: increased level

Potassium: decreased level

Drug-behaviors.Alcohol use: impaired cardiac tolerance of formoterol

Patient monitoring

• Monitor pulmonary function test results.
• Monitor potassium and glucose levels.

Patient teaching

• Teach patient how to use capsules and Aerolizer inhaler provided.
• Instruct patient to keep capsules in blisters until immediately before use.
• Caution patient not to swallow capsules.
• Tell patient not to use drug for acute asthma attacks.

Instruct patient to contact prescriber immediately if difficulty in breathing persists after using drug or if condition worsens.
• Caution patient to take drug exactly as prescribed and not to stop therapy even if he feels better.
• Tell patient to consult prescriber if he has been taking inhaled, short-acting drugs on a regular basis.
• Advise female patient to tell prescriber if she is pregnant or breastfeeding or if she plans to become pregnant.
• Caution patient to avoid alcohol during therapy.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

formoterol fumarate

(fôr-mō′tə-rôl′, -rōl′)
n.
A drug used in the treatment of asthma, the prevention of bronchospasm, and the maintenance treatment of chronic obstructive pulmonary disease.

formoterol fumarate

a beta-adrenergic agonist used to treat chronic obstructive pulmonary disorder, maintain and treat asthma, and prevent exercise-induced bronchospasm.
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References in periodicals archive ?
Currently, three combinations of inhaled corticosteroid plus long-acting beta-agonists are available for the treatment of COPD, but not this particular combination of mometasone furoate with formoterol fumarate administered with a metered-dose inhaler, which is licensed for asthma treatment in the United States under the name Dulera, Dr.
DULERA (mometasone furoate and formoterol fumarate dihydrate) Inhalation Aerosol is indicated for the treatment of asthma in patients 12 years and older.
Each clear, hard gelatin capsule contains a dry powder blend of 12 mcg of formoterol fumarate and 25 mg of lactose (which contains trace levels of milk proteins) as a carrier.
The study is a Phase III multi-centre, randomised, double-blind and double dummy, placebo and active-controlled, parallel-group study comparing fluticasone propionate / formoterol fumarate 250/10 ?
AUGMENT ( A clidinium/formoterol F U murate Combination for Investi G ative use in the Treat MENT of Moderate to Severe COPD) was a 24-week randomized double-blind trial evaluating the 400/12mcg and 400/6mcg fixed dose combinations of aclidinium bromide/formoterol fumarate compared with aclidinium bromide 400mcg, formoterol fumarate 12mcg and placebo administered BID through the Pressair inhaler (Genuair outside the USA) in 1,692 patients with moderate to severe COPD in the USA, Australia and New Zealand.
glycopyrrolate + formoterol fumarate + budesonide) 129
NYSE:FRX) today announced positive topline results from a six month pivotal phase III clinical trial evaluating the efficacy and safety of fixed dose combinations of aclidinium bromide (LAMA) and formoterol fumarate (LABA) delivered by Almirall's inhaler Genuair[sup.
Tenders are invited for Respules Formoterol Fumarate Dihydrate Respules Formoterol Fumarate Dihydrate Equivalent To Formoterol Fumarate 20 Mcg Budesonide 0.
Tenders are invited for Budesonide 200Mcg With Formoterol Fumarate 6Mcg I
MC) today announced that, together with its US partner Forest, initiated a Phase III clinical programme of the fixed dose combination (FDC) of aclidinium bromide and formoterol fumarate twice daily (BID) delivered in the Genuair[sup.