FOXO1

(redirected from forkhead box O1)

FOXO1

The gene on chromosome 13q14.1 which encodes a forkhead family transcription factor that regulates cell responses to oxidative stress. In the presence of KIRT1, it downregulates cyclin D1 and upregulates CDKN1B as required for cell transition from proliferation to quiescence. It may play a role in myogenic growth and differentiation.

Molecular pathology
FOXO1 translocation with PAX3 has been associated with alveolar rhabdomyosarcoma.
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In the hepatic response to fasting, PGC-1[alpha] has been shown to coordinate the induction of gluconeogenic enzymes by coactivating such liver-enriched transcription factors as hepatocyte nuclear factor 4[alpha] (HNF4[alpha]) and forkhead box O1 protein (FOXO1), as well as the glucocorticoid receptor (3).
1] Nonstandard abbreviations: hepcidinl, mouse hepcidin antimicrobial peptide 1; PGC-1[alpha], peroxisome proliferator-activated receptor [gamma] coactivator 1[alpha]; HNF4[alpha], hepatocyte nuclear factor 4[alpha]; FOXO1, forkhead box O1 protein.