FOXP1

(redirected from fork-head-related protein like B)
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FOXP1

(1) A transcription-factor protein encoded by FOXP1 on chromosome 3p14.1, which belongs to subfamily P of the fork-head box transcription-factor family. It has DNA- and protein-binding domains, and plays an important role in cell transformation, differentiation and proliferation.

Normal expression
FOXP1 is widely expressed in normal tissues, and has a predominantly nuclear location in proliferative endometrium and weak cytoplasmic staining in secretory endometerium.

Abnormal expression
Loss of nuclear FOXP1 expression or mislocation in cytoplasm is typical of malignancy—e.g., invasive endometrial carcinoma.

(2) A gene on chromosome 3p14.1 which encodes a winged-helix transcription-factor (FOXP1) in the fork-head box family, which has a key role in cell transformation, differentiation and proliferation.
 
Abnormal expression
FOXP1 overexpression is associated with a lower disease-free survival in diffuse, large B-cell lymphoma.