folic acid antagonists


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fo·lic ac·id an·tag·o·nists

modified pterins, such as aminopterin and methotrexate, which interfere with the action of folic acid and thus produce the symptoms of folic acid deficiency; have been used in cancer chemotherapy and inflammatory disorders.

folic acid antagonists

Drugs used to treat RHEUMATOID ARTHRITIS, PSORIASIS and various cancers. An example is methotrexate (Maxtrex). folie à deux , a rare delusional psychotic disorder affecting two, usually isolated, people who gain mutual advantage from the situation. It is sometimes called ‘shared paranoid disorder’. The more dominant of the two has a delusional psychosis and the submissive person gains the approval of the other by accepting the delusions. At the same time, the dominant person retains some link with the real world through the medium of the partner. Cases ranging from folie à trois to folie à douze have been reported.
References in periodicals archive ?
FUSILEV is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination, and of inadvertent overdosage of folic acid antagonists.
LEVOleucovorin is indicated after high-dose methotrexate therapy in patients with osteosarcoma, and to diminish the toxicity and counteract the effects of impaired methotrexate elimination or inadvertent overdose of folic acid antagonists.