Some women with iron deficiency due to bariatric surgery or malabsorption also have vitamin B12 and, less commonly, folate deficiency
, which can contribute to the development of anemia (see "Diagnosis of anemia, iron deficiency, and iron deficiency anemia in pregnancy.
Diagnosis and treatment of vitamin B12 and folate deficiency
12] and folate deficiency
and bone marrow disorders and normal in liver disease and alcohol use.
Macrocytosis is the earliest indication seen in complete blood counts of patients with vitamin B12 or folate deficiency
4 However, previously there has been no detailed study in Pakistan of the biochemical etiology of this anemia, exploring the relative contributions of iron, vitamin B12 and folate deficiency
The megaloblastic anemias are disorders caused by impaired DNAsynthesis usually due to vitamin B12 or folate deficiency
If not received regularly, folate deficiency
occurs in 2-3 months.
Those with a folate deficiency
were found to be almost three-and-a-half times more likely to develop dementia.
According to the researchers, this threshold is higher than the standard cutoff for diagnosing folate deficiency
(less than 10 nm/L).
(serum folate 4 ng/mL or red blood cell folate < 151 ng/mL) and vitamin B12 deficiency (plasma vitamin B12 < 203 pg/mL) were obtained as a national prevalence.
Table 1: Prevalence of vitamin B12 and folate deficiency
B12 and folate deficiency
was detected in 10% and 7% patients respectively.