Caspase-3 is one of the key executioners of apoptosis, capable of cleaving or degrading many key proteins including nuclear lamins, fodrin
as well as PARP (Lawen 2003).
Loss of overall cell shape is probably due to the cleavage of cytoskeletal proteins such as fodrin
and gelsolin (Kothakota, 1997) and finally the plasma membrane blebbing seems to be caused by the cleavage of PAK2, a member of the p21-activated kinases family (Rudel and Bokoch, 1997).
Immunolocalization of the fodrin
, E-cadherin, and beta-catenin adhesion complex in infiltrating ductal carcinoma of the breast-comparison with an in vitro model.
F numbers Critical Molecules (Gauss) (Hz) 1 Spectrin, Brain Specific Fodrin
This oxidative damage also pledges the apoptotic changes like production of fodrin
proteins and cleavage of cytoskeleton gelsolin and increased caspase activated DNase (CAD) in the nucleus which is responsible for the degradation, breakdown and disintegration of nuclear lamins proteins (Fernandes et al.