focal segmental glomerulosclerosis


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Related to focal segmental glomerulosclerosis: Minimal change disease, membranoproliferative glomerulonephritis

glomerulosclerosis

 [glo-mer″u-lo-sklĕ-ro´sis]
diabetic glomerulosclerosis (intercapillary glomerulosclerosis) a degenerative complication of diabetes mellitus in which there is glomerular mesangial expansion with either diffuse lesions or nodular (Kimmelstiel-Wilson) lesions; symptoms include albuminuria, nephrotic edema, hypertension, renal insufficiency, and retinopathy. The type with nodular lesions is also called Kimmelstiel-Wilson syndrome.
focal segmental glomerulosclerosis focal sclerosing lesions of the renal glomeruli, with proteinuria, hematuria, hypertension, and the nephrotic syndrome; it may be idiopathic or secondary to another condition. Called also focal glomerular sclerosis.

fo·cal seg·men·tal glo·mer·u·lo·scle·ro·sis

segmental collapse of glomerular capillaries with thickened basement membranes and increased mesangial matrix; seen in some glomeruli of patients with nephrotic syndrome or mesangial proliferative glomerulonephritis.

fo·cal seg·men·tal glo·mer·u·lo·scle·ro·sis

(fō'kăl seg-men'tăl glo-mer'yū-lō-skler-ō'sis)
Segmental collapse of glomerular capillaries with thickened basement membranes and increased mesangial matrix; seen in some glomeruli of patients with nephrotic syndrome or mesangial proliferative glomerulonephritis.

focal segmental glomerulosclerosis

An irreversible form of glomerular injury often seen in patients with a history of injection drug use or acquired immunodeficiency syndrome.
References in periodicals archive ?
Collapsing focal segmental glomerulosclerosis in a patient with systemic lupus erythematosus.
Huber, "New players in the pathogenesis of focal segmental glomerulosclerosis," Nephrology Dialysis Transplantation, vol.
Frequency and clinicopathological correlations of histopathological variants of pediatric idiopathic focal segmental glomerulosclerosis.
Studies in Iran done in children with Nephrotic syndrome also showed, focal segmental glomerulosclerosis was the most common pathologic finding (41%).
In addition, focal segmental glomerulosclerosis (FSGS), membranoproliferative glomerulonephritis (MPGN), mesangial proliferation, proliferative glomerulonephritis and membranous glomerulopathy may also be observed (2).
Therefore, to further address this issue we decided to analyse retrospectively NPHS1, NPHS2, WT1 (exons 8 and 9 and the adjacent exon/intron boundaries) and LAMB2 genes in DNA samples from 33 patients with steroid-resistant focal segmental glomerulosclerosis manifesting before adolescence.
Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice.
Kopp, "Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States," American Journal of Kidney Diseases, vol.
Primary idiopathic NS may be associated with at least 3 different histologic abnormalities: minimal-change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (1).
Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants.
The NephCure Foundation is the only organization committed exclusively to supporting research to identify the cause, improve treatment and ultimately find a cure for the potentially debilitating kidney diseases Focal Segmental Glomerulosclerosis Syndrome and Nephrotic Syndrome.
Focal segmental glomerulosclerosis was found in 22 cases (22%) followed by membranous nephropathy in17 cases (17%), IgA nephropathy and mesangioproliferative glomerulonephritis in 10 cases (10%) each.