dysplasia

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dysplasia

 [dis-pla´zhah]
an abnormality of development; in pathology, alteration in size, shape, and organization of adult cells. See also dysgenesis. adj., adj dysplas´tic.
bronchopulmonary dysplasia chronic lung disease of premature infants with hyaline membrane disease who have needed high concentrations of oxygen and assisted ventilation. Factors related to its development include alveolar damage due to hyaline membrane disease, oxygen toxicity, positive pressure ventilation, and endotracheal intubation. Treatment includes supportive measures and oxygen therapy. Recovery and normal pulmonary function usually occur by the age of 6 months to 1 year; however, some infants may exhibit limited tolerance to exercise.
craniometaphyseal dysplasia metaphyseal dysplasia associated with overgrowth of the head bones, leonine facies, and increased distance between the eyes.
Craniometaphyseal dysplasia. From Dorland's, 2000.
cretinoid dysplasia a developmental abnormality characteristic of cretinism, consisting of retarded ossification and smallness of the internal and reproductive organs.
cystic renal dysplasia renal dysplasia in which there are cysts.
developmental dysplasia of the hip (DDH) instability of the hip joint leading to dislocation in the neonatal period. Although it may be associated with various neuromuscular disorders, such as myelodysplasia, or occur in utero, it most commonly occurs in neurologically normal infants and is multifactorial in origin. Usually there is laxity of the hip ligaments. Most affected infants are first-born children and 30 to 50 per cent present in the breech position. About 90 per cent of those affected are girls. The condition was formerly called congenital dislocation of the hip, but because the dislocation is not normally present at birth but develops later, the term developmental dysplasia of the hip is preferred.
ectodermal dysplasia any of a group of hereditary disorders involving absence or deficiency of tissues and structures derived from the embryonic ectoderm, such as teeth, hair, nails, and certain glands.
fibromuscular dysplasia dysplasia with fibrosis of the muscular layer of an artery wall, with collagen deposition and hyperplasia of smooth muscle, causing stenosis and hypertension. It most commonly occurs in the renal arteries and is a major cause of renovascular hypertension.
fibrous dysplasia of bone thinning of the cortex of bone and replacement of bone marrow by gritty fibrous tissue containing bony spicules, causing pain, disability, and gradually increasing deformity; it may affect a single bone (monostotic fibrous dysplasia) or several or many bones (polyostotic fibrous dysplasia). When associated with melanotic pigmentation of the skin and endocrine disorders, it is known as albright's syndrome.
metaphyseal dysplasia a disturbance in enchondral bone growth, failure of modeling causing the ends of the shafts to remain larger than normal in circumference.
oculodentodigital dysplasia a rare hereditary condition, characterized by bilateral microphthalmos, abnormally small nose with anteverted nostrils, hypotrichosis, dental anomalies, camptodactyly, syndactyly, and missing phalanges of the toes.
renal dysplasia a congenital disorder of the kidney, with persistence of cartilage, undifferentiated mensenchyme, and immature collecting tubules, as well as with abnormal lobar organization and nearly always cysts; it may be unilateral or bilateral and total or subtotal. Total bilateral dysplasia is rapidly fatal in the neonatal period, while milder disease may be asymptomatic.
retinal dysplasia a general term for a congenital defect resulting from the abnormal growth and differentiation of a retina that fails to develop into functioning tissue.

dys·pla·si·a

(dis-plā'zē-ă),
Abnormal tissue development.
See also: heteroplasia.
[dys- + G. plasis, a molding]

dysplasia

/dys·pla·sia/ (dis-pla´zhah)
1. abnormality of development.
2. in pathology, alteration in size, shape, and organization of adult cells.dysplas´tic

anhidrotic ectodermal dysplasia  an inherited disorder characterized by ectodermal dysplasia associated with aplasia or hypoplasia of the sweat glands, hypothermia, alopecia, anodontia, conical teeth, and facial abnormalities.
anteroposterior facial dysplasia  defective development resulting in abnormal anteroposterior relations of the maxilla and mandible to each other or to the cranial base.
arrhythmogenic right ventricular dysplasia  a congenital cardiomyopathy in which transmural infiltration of adipose tissue results in weakness and bulging of regions of the right ventricle and leads to ventricular tachycardia arising in the right ventricle.
bronchopulmonary dysplasia  a chronic lung disease of infants, possibly related to oxygen toxicity or barotrauma, characterized by bronchiolar metaplasia and interstitial fibrosis.
chondroectodermal dysplasia  achondroplasia with defective development of skin, hair, and teeth, polydactyly, and defect of cardiac septum.
cretinoid dysplasia  a developmental abnormality characteristic of cretinism, consisting of retarded ossification and smallness of the internal and sexual organs.
developmental dysplasia of the hip  (DDH) instability of the hip joint leading to dislocation in the neonatal period; it may be associated with various neuromuscular disorders or occur in utero but occurs most commonly in neurologically normal infants and is multifactorial in origin. Formerly called congenital dislocation of the hip.
diaphyseal dysplasia  thickening of the cortex of the midshaft area of the long bones, progressing toward the epiphyses, and sometimes also in the flat bones.
ectodermal dysplasia  any of a group of hereditary disorders involving tissues and structures derived from embryonic ectoderm, including anhidrotic ectodermal dysplasia, hidrotic ectodermal dysplasia, and EEC syndrome.
epiphyseal dysplasia  faulty growth and ossification of the epiphyses with radiographically apparent stippling and decreased stature, not associated with thyroid disease.
fibromuscular dysplasia  dysplasia with fibrosis of the muscular layer of an artery wall, with collagen deposition and hyperplasia of smooth muscle, causing stenosis and hypertension; seen most often in renal arteries, it is a major cause of renovascular hypertension.
fibrous dysplasia of bone  thinning of the cortex of bone and replacement of bone marrow by gritty fibrous tissue containing bony spicules, causing pain, disability, and gradually increasing deformity; only one bone may be involved (monostotic fibrous d.), with the process later affecting several or many bones (polyostotic fibrous d.) .
florid osseous dysplasia  an exuberant form of periapical cemental dysplasia resembling diffuse sclerosing osteomyelitis but not inflammatory.
hidrotic ectodermal dysplasia  an inherited disorder of ectodermal dysplasia with tooth abnormalities, hypotrichosis, cutaneous hyperpigmentation over joints, and hyperkeratosis of the palms and soles.
metaphyseal dysplasia  a disturbance in enchondral bone growth, failure of modeling causing the ends of the shafts to remain larger than normal in circumference.
oculodentodigital dysplasia  a rare autosomal dominant condition, characterized by bilateral microphthalmos, abnormally small nose with anteverted nostrils, hypotrichosis, dental anomalies, camptodactyly, syndactyly, and missing phalanges of the toes.
periapical cemental dysplasia  a nonneoplastic condition characterized by formation of areas of fibrous connective tissue, bone, and cementum around the apex of a tooth.
septo-optic dysplasia  a syndrome of hypoplasia of the optic disk with other ocular abnormalities, absence of the septum pellucidum, and hypopituitarism leading to growth deficiency.
spondyloepiphyseal dysplasia  hereditary dysplasia of the vertebrae and extremities resulting in dwarfism of the short-trunk type, often with shortened limbs due to epiphyseal abnormalities.
thanatophoric dysplasia  a uniformly fatal type of skeletal dysplasia presenting as extreme shortness of the limbs, thoracic cage deformity, and relative enlargement of the head.

dysplasia

(dĭs-plā′zhə)
n.
Abnormal development or growth of tissues, organs, or cells.

dys·plas′tic (-plăs′tĭk) adj.

dysplasia

[displā′zhə]
Etymology: Gk, dys + plassein, to form
any abnormal development of tissues or organs. An alteration in cell growth resulting in cells that differ in size, shape, and appearance, often as a result of chronic irritation. Common sites for dysplasia are the respiratory tract in smokers and the cervix.
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Top, Mild dysplasia

dysplasia

Defective growth Pediatrics
1. Altered growth of a tissue or structure Examples Anhidrotic ectodermal dysplasia–Christ-Siemans syndrome, Holt-Oram syndrome–atrial digital dysplasia, chondroectodermal dysplasia–Ellis-van Creveld syndrome, hidrotic ectodermal dysplasia–
Clouston syndrome, metaphyseal dysplasia–Pyle's disease, oculoauriculovertebral dysplasia–Goldenhaar syndrome, oculodentodigital dysplasia–ODD syndrome, olfactogenital syndrome–Kallmann syndrome, and progressive diaphyseal dysplasia–Camurati-Engelmann syndrome. See Anhidrotic ectodermal dysplasia, Congenital hip dysplasia, Coronal dysplasia, Cortical dysplasia, Familial focal facial dermal dysplasia, Fibrodysplasia ossificans progressiva, Hypohidrotic dysplasia, Metaphyseal chondrodysplasia, OSMED dysplasia, Osteofibrous dysplasia, Otopalatodigital dysplasia, Radicular dentin dysplasia, Retinal dysplasia, Right ventricular dysplasia, Septo-optic dysplasia, Spondyloepiphyseal dysplasia, Valve dysplasia.
3. Fibrous dysplasia, see there Imaging A term for unusual shadows seen on a mammogram which suggest possible breast CA. See Breast cancer, Mammography. Cf Mammary dysplasia Surgical pathology A premalignant lesion of epithelia, especially squamous epithelium of the uterine cervix, oral cavity, upper respiratory tract, penis, anus, etc; epithelial dysplasia may be induced by HPV, especially types 16, and is synonymous with intraepithelial neoplasia, the term preferred by pathologists. See Bowenoid dysplasia, Minimal cervical dysplasia. See Ductal intraepithelial neoplasia, Fibrocystic disease, Mammary dysplasia.

dys·pla·si·a

(dis-plā'zē-ă)
Abnormal tissue development.
See also: heteroplasia

dysplasia

An abnormal alteration in a tissue due to abnormality in the function of the component cells, but excluding cancer. There may be absence of growth, abnormal increase in growth or abnormalities in cell structure. Dysplasia in an epithelium commonly progresses to cancer.

dysplasia

abnormal growth or development, as may occur in organs or cells.

Dysplasia

The abnormal change in size, shape or organization of adult cells.

dysplasia

abnormal tissue development

dysplasia (dis·plāˑ·zh),

n abnormal cell growth or growth patterns in tissues or organs.
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Dysplasia.

dys·pla·si·a

(dis-plā'zē-ă, dis-plāzē-ă)
Abnormal tissue development.

dysplasia (displā´zhə),

n 1. a developmental abnormality. See also dysplasia, dentinal.
n 2. the reversible, regressive alteration in adult cells, seen as alterations in their size, shape, orientation, and functions; leads to change in tissue architecture and is related to chronic inflammation or protracted irritation.
3. an abnormality of development.
n 4. a disharmony between component parts.
dysplasia, anteroposterior (anteroposterior facial dysplasia),
n an abnormal anteroposterior relationship of the maxillae and mandible to each other or to the cranial base.
dysplasia, cementoosseous,
n a fairly common benign fibroosseous lesion (BFOL) that appears in the jawbone. They appear on radiographic examinations as highly visible areas of mixed radiolucent/radiopaque bone. The three categories of cementoosseous dysplasia are focal, periapical, and florid. Such lesions are easily diagnosed with radiographic examination and do not require a biopsy, which can damage adjacent bone tissue.
dysplasia, cleidocranial
(klī´dōkrā´-nēəl),
n (Sainton's disease), a familial disease or congenital disorder characterized by failure to form, or retarded formation of, the clavicles; delayed closure of the sutures and fontanels; and delayed eruption of teeth, with formation of supernumerary teeth. It is characterized by underdevelopment of the maxillae, agenesis or aplasia of the clavicle, abnormalities in other skeletal bones and muscles, and irregularities of the dentition. The syndrome may be mutational or transmitted on an autosomal dominant basis.
dysplasia, craniofacial,
n a disharmony between the cranium and the face.
dysplasia, dentinal,
n a genetic disturbance of the dentin characterized by early calcification of the pulp chambers and root canals and by root resorption. It is differentiated from dentinogenesis imperfecta by the latter's characteristics of attrition and relative freedom from root resorption.
dysplasia, dentofacial,
n a disharmony between teeth and bones of the face (e.g., crowding and spacing).
dysplasia, ectodermal
n a group of diseases characterized by failure to form two or more ectodermal derivatives. Sweat glands and teeth may be missing (anhidrosis and hypodontia, respectively), and there may be scant hair, faulty fingernails, and malformation of the iris.
dysplasia, enamel,
n a development abnormality of enamel tissue.
dysplasia, fibroosseous,
n See dysplasia, fibrous.
dysplasia, fibrous (fibroosseous dysplasia),
n a metabolic disturbance characterized by replacement of the bone marrow with fibrous tissue and slow, progressive remolding and enlargement of the bone. It may be monostotic (limited to one bone) or polyostotic (present in many bones). McCune-Albright syndrome shows polyostotic fibrous dysplasia and other symptoms. See also syndrome, McCune-Albright.
dysplasia, focal osseous,
dysplasia, maxillomandibular
n a disharmony between one jaw and the other.
(os´ēəs),
n a chronic reaction of the bone to injury characterized by replacement of the bone marrow with fibrous connective tissue, unilateral enlargement of the maxillae or mandible, and characteristic radiographic findings. It is similar or identical to monostotic fibrous dysplasia and ossifying fibroma.
dysplasia, polyostotic fibrous
(pol´ēostot´ik fīb´rəs),
n the disease of fibrous dysplasia occurring in more than one bone. See also dysplasia, fibrous; osteofibroma; and syndrome, Albright's.

dysplasia

an abnormality of development; in pathology an alteration in size, shape and organization of adult cells.

black hair follicular dysplasia
a familial disorder of hair follicles in dogs, occurring only in areas with black pigmentation. Affected dogs have a normal haircoat except in black areas where hair growth is thin and the skin scaly.
canine hip dysplasia
see hip dysplasia.
occipital dysplasia
congenital enlargement of the foramen magnum, sometimes associated with hydrocephalus or cerebellar herniation or spina bifida. Observed most often in toy breeds of dogs.