focal glomerular sclerosis

focal glomerular sclerosis,

focal sclerosing lesions of renal glomeruli with proteinuria, hematuria, hypertension, and the nephrotic syndrome. It may be idiopathic or secondary to other conditions, including heroin-abuse nephropathy, chronic interstitial nephritis, and malignancies. Exacerbations and remissions may occur, most often in children; progression to renal failure occurs at a variable and unpredictable rate. Also called focal glomerulosclerosis.

---

sclerosis [sklĕ-ro´sis]

an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels. Called also induration. adj., adj sclerot´ic.

amyotrophic lateral sclerosis see amyotrophic lateral sclerosis.

arteriolar sclerosis arteriolosclerosis.

disseminated sclerosis multiple sclerosis.

familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria, and mental deterioration.

focal glomerular sclerosis focal segmental glomerulosclerosis.

glomerular sclerosis glomerulosclerosis.

hippocampal sclerosis loss of neurons in the region of the hippocampus, with gliosis; sometimes seen in epilepsy.

lateral sclerosis a form seated in the lateral columns of the spinal cord. It may be primary, with spastic paraplegia, rigidity of the limbs, and increase of the tendon reflexes but no sensory disturbances, or secondary to myelitis, with paraplegia and sensory disturbance.

medial calcific sclerosis (Mönckeberg's sclerosis) Mönckeberg's arteriosclerosis.

multiple sclerosis see multiple sclerosis.

systemic sclerosis systemic scleroderma.

tuberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain (tubers), retina (phakomas), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions.