BMI1

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BMI1

A gene on chromosome 10p11.23, which encodes one of the proteins that participate in the Polycomb group (PcG) multiprotein PRC1-like complex, a complex group of proteins needed to maintain an array of genes (e.g., Hox genes) in a state of transcriptional repression during development. The PcG PRC1 complex acts via chromatin remodelling and histone modification.