fluorocitrate

fluorocitrate

a metabolic product of fluoroacetic acid which inhibits aconitase and causes the tissue build-up of citrate, the pathogenesis of fluoroacetate poisoning.
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Hindbrain glucoprivation effects on gastric vagal reflex circuits and gastric motility in the rat are suppressed by the astrocyte inhibitor fluorocitrate.
Fluorocitrate binds irreversibly to the enzyme aconitase, thereby stopping the citric acid cycle, which stops the production of the essential cellular energy molecule ATP.
The first organic fluorine compound identified, in 1943, was fluoracetate, which may cause death in grazing animals, because it is transferred to fluorocitrate and irreversibly bound to aconitase, thereby blocked the citrate cycle.