fluorescein staining


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Related to fluorescein staining: blepharitis, cataract

staining, fluorescein 

The artificial coloration of tissue by fluorescein. Under ultraviolet illumination, it stains dead or degenerated corneal epithelial cells due to abrasions, old age or following inadequate contact lens fit, a yellowish-green colour. It also stains the tears, thus facilitating the evaluation of tear drainage or the blood flow through the retina and choroid when injected intravenously. Corneal staining resulting from contact lens wear may present in various shapes, locations, depths or severity. A very common form is punctate staining as appears in punctate epithelial keratitis. There may be arcuate stains located in different parts of the cornea, some inferiorly (called inferior epithelial arcuate lesions) or superiorly (called superior epithelial arcuate lesions, acronym: SEAL, or epithelial splitting), which usually do not give rise to symptoms and appear mainly with soft or silicone hydrogel lenses. A very severe form of staining is called epithelial plug. It is typically round in shape and represents a loss of the full thickness of the epithelium. Corneal staining resulting from contact lens wear typically disappears after cessation of contact lens wear. See fluorescein angiography; dye dilution test; fluorescein test.
References in periodicals archive ?
Tear breakup time in seconds was taken as interval between last blink and appearance of first dry spot on the cornea after fluorescein staining while viewing with cobalt blue filter on slitlamp biomicroscope (Topcon).
On day 10, the corneal fluorescein staining scores significantly increased in the EDE group (12.
sup][15] The criteria for diagnosis of severe dry eye disease were as follows: (a) Ocular Surface Disease Index (OSDI) ≥33 and corneal fluorescein staining (CFS) score ≥3; (b) OSDI <33 and CFS ≥3, additional criteria ≥1 or impaired corneal sensitivity; (c) OSDI ≥33 and CFS = 2, additional criteria ≥1; (d) OSDI ≥3 and CFS ≤1, additional criteria ≥1 and BUT <3 s.
Consistent with the reduction of ocular discomfort and fluorescein staining at the 28-day follow-up visit, other improvements seen in the RGN-259-treated patients included tear film breakup time and increased tear volume production.
A brief physical examination was performed, direct pupillary light reflex was tested, and fluorescein staining was performed on each eye of each bird 24 hours after administration.
Punctate corneal fluorescein staining was positive, indicating damage to the cornea in his right eye.
The first, Professor Christine Purslow, showed us that signs of dry eye go far beyond fluorescein staining, and demonstrated how important symptoms are in dry eye diagnosis.
In a previous Phase II study, in which was CF101 taken orally as a monotherapy for 12 weeks, a statistically significant benefit in the clearing of fluorescein staining in the nasal, temporal, pupillary and inferior parts of the cornea was documented.
Reduction from baseline in central corneal fluorescein staining compared to placebo at the 24 hour recovery period (p = 0.
6%) patients, fluorescein staining revealed punctate epithelial erosions in 7(19.

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