fluorescein staining


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Related to fluorescein staining: blepharitis, cataract

staining, fluorescein 

The artificial coloration of tissue by fluorescein. Under ultraviolet illumination, it stains dead or degenerated corneal epithelial cells due to abrasions, old age or following inadequate contact lens fit, a yellowish-green colour. It also stains the tears, thus facilitating the evaluation of tear drainage or the blood flow through the retina and choroid when injected intravenously. Corneal staining resulting from contact lens wear may present in various shapes, locations, depths or severity. A very common form is punctate staining as appears in punctate epithelial keratitis. There may be arcuate stains located in different parts of the cornea, some inferiorly (called inferior epithelial arcuate lesions) or superiorly (called superior epithelial arcuate lesions, acronym: SEAL, or epithelial splitting), which usually do not give rise to symptoms and appear mainly with soft or silicone hydrogel lenses. A very severe form of staining is called epithelial plug. It is typically round in shape and represents a loss of the full thickness of the epithelium. Corneal staining resulting from contact lens wear typically disappears after cessation of contact lens wear. See fluorescein angiography; dye dilution test; fluorescein test.
References in periodicals archive ?
CSF leaks were ascertained by fluorescein staining (intrathecal fluorescein application) in all instances.
The primary objective of the study is to determine the safety of EBI-005 and, in addition, an assessment of biological activity of EBI-005 will be measured by the Ocular Surface Disease Index (OSDI) and corneal fluorescein staining.
The reduction of fluorescein staining is indicative of a reduction in ocular surface damage of the cornea while improvement in ocular discomfort reflects how the patient's eye feels.
Fluorescein staining demonstrated no corneal ulcers, and the bird was discharged with flurbiprofen (1 drop OD q12h for 10 days; Ocufen, Allergan Inc, Irvine, CA, USA) and neomycin/polymyxin B (1 drop OD q12h for 10 days).
1% reduction of total corneal fluorescein staining compared to vehicle control (p=0.
3) However, studies have shown that fluorescein staining is due to uptake of fluorescein by individual corneal epithelial cells following microscopic examination of excised rabbit eyes, and not by fluorescein pooling in areas of epithelial cell drop out or filling of intracellular spaces.

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