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a steroid antiinflammatory agent administered as an aerosol spray for treatment of bronchial asthma and seasonal or perennial allergic rhinitis when conventional treatment is unsatisfactory.


APO-Flunisolide (CA), Nasarel, PMS-Flunisolide (CA), Ratio-Flunisolide (CA), Rhinalar Nasal Mist (CA)

Pharmacologic class: Intranasal steroid

Therapeutic class: Respiratory inhalant

Pregnancy risk category C


Unknown. Thought to diminish capillary permeability and suppress migration of polymorphonuclear leukocytes, decreasing inflammation.


Spray solution: 25 ml (each actuation delivers approximately 25 mcg)

Indications and dosages

Relief of seasonal or perennial rhinitis

Adults: Two sprays in each nostril b.i.d.; may increase to two sprays in each nostril t.i.d. Maximum daily dose is eight sprays in each nostril. For maintenance, after desired clinical effect occurs, reduce dosage to smallest amount needed to control symptoms.

Children ages 6 to 14: One spray in each nostril t.i.d. or two sprays in each nostril b.i.d.; maximum daily dose is four sprays in each nostril. For maintenance, after desired clinical effect occurs, reduce dosage to smallest amount needed to control symptoms.


• Hypersensitivity to drug or its components
• Untreated local infections of nasal mucosa


Use cautiously in:
• localized Candida albicans infection; tuberculosis; untreated fungal, bacterial, or systemic viral infections; ocular herpes simplex
• patients receiving immunosuppressive therapy.


• Don't increase dosage or discontinue drug abruptly.

Adverse reactions

CNS: headache, light-headedness, nervousness, dizziness

EENT: cataracts; glaucoma; blurred vision; conjunctivitis; increased intraocular pressure; lacrimation; dry, irritated eyes; tinnitus; otitis; otitis media; rhinorrhea; rhinitis; nasal irritation, burning, and dryness; nasal stuffiness and pain; sneezing; nasal ulcer; epistaxis; localized Candida albicans nasal infections; nasal mucosa ulcerations; nasal septum perforation; throat discomfort, soreness, and dryness; mild nasopharyngeal irritation; pharyngitis; dry mucous membranes; nasal and sinus congestion; sinusitis; hoarseness, voice changes

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth

Metabolic: hyperadrenocorticism

Musculoskeletal: myalgia, arthralgia, aseptic necrosis of femoral head

Respiratory: wheezing, dyspnea, increased cough, bronchitis, bronchospasm, asthma symptoms

Skin: rash, pruritus, urticaria, contact dermatitis, alopecia, herpes simplex infection

Other: altered taste and smell, facial edema, fever, flulike symptoms, aches and pains, infections, angioedema, anaphylaxis


Drug-diagnostic tests.Aspartate aminotransferase: increased level

Patient monitoring

Monitor patient closely for serious adverse reactions, including anaphylaxis, angioedema, hyperadrenocorticism, and serious infections.

Patient teaching

Teach patient to recognize and immediately report serious adverse reactions.
• Teach patient proper use of drug. Caution him not to use more than prescribed amount; doing so may cause serious side effects.
• Tell patient maximum drug effects may not occur for several weeks.
• Tell patient to avoid people with measles, chickenpox, and other transmissible infections.
• Caution patient to withhold dose and contact prescriber if infection occurs.
• Instruct female patient to tell prescriber if she becomes pregnant.
• Tell female patient not to breastfeed without consulting prescriber.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.


/flu·nis·o·lide/ (floo-nis´o-līd″) a synthetic glucocorticoid used as the acetate salt in treatment of bronchial asthma and seasonal and nonseasonal allergic rhinitis.


A corticosteroid, C24H31FO6, administered by inhalation to treat asthma and nasally to treat allergies.


an intranasal and oral inhalation adrenal corticosteroid.
indications It is prescribed in the treatment of seasonal or continuing allergic rhinitis that involves inflammation of the mucous membranes of the nasal passages and for the treatment of asthma.
contraindications It should not be given to patients with allergy to this drug or any of its components or to patients with status asthmaticus or untreated bacterial, viral, or fungal infections of the respiratory tract or nasal mucosa.
adverse effects The side effects most often reported include nasal or throat irritation, stinging, burning, or dryness; nosebleed; sneezing; bloody mucus; congestion; asthma; increased coughing; sore throat; or lesions in the nose or throat.


Aerobid® An inhalant corticosteroid used to manage asthma


A CORTICOSTEROID drug used in the form of a spray to treat hay fever. A brand name is Syntaris.


n brand name: Oral INH aerosol, AeroBid;
drug class: synthetic glucocorticoid;
action: long-acting synthetic adrenocorticoid with antiinflammatory activity;
use: rhinitis (seasonal or perennial).
References in periodicals archive ?
In contrast, 56% of beclomethasone HFA and 68% of flunisolide HFA particles are deposited in the lung.
Similarly, the isomers triamcinolone acetonide and flunisolide also need to be separated chromatographically from each other because of similar precursor and product ions.
Her asthma was managed on inhaled flunisolide, cromolyn, an albuterol inhaler as needed, nasal cromolyn, and diphenhydramine.
The absence of blood eosinophilia combined with retention of a florid tissue eosinophilia in our patient was likely due to flunisolide, an anti-inflammatory steroid with the ability to cause reduction of circulating eosinophils.
Efficacy of beclomethasone nasal solution, flunisolide and cromolyn in relieving symptoms of ragweed allergy.
Other ICS used for controlling asthma in steps two through six include beclamethasone, budesonide, flunisolide, mometasone, ciclesonide and triamcinolone.
Other CFC-based medications include the corticosteroids triamcinolone and flunisolide, the mast cell stabilizers cromolyn and nedocromil, and the [beta]-agonists metaproterenol, pirbuterol, and combined albuterol-ipratropium.
Six aqueous INS formulations are currently licensed for the treatment of adult and pediatric PAR in the US: beclomethasone dipropionate (BDP), budesonide, flunisolide, fluticasone propionate (FP), mometasone furoate (MF) and triamcinolone acetonide (TAA).
However, one study examined the addition of high, cumulative doses of inhaled flunisolide added to albuterol in emergency room treatment of acute adult asthma.
Another drug, flunisolide, which is currently in the Food and Drug Administration pipeline, is formulated so that one HFA puff supplies a an equivalent dose to one CFC puff.
Some drugs for allergic rhinitis (a) Drug Adult dosage Corticosteroid nasal sprays Beclomethasone dipropionate 1 or 2 sprays per nostril, bid (Beconase AQ; GlaxoSmithKline) Budesonide (Rhinocort Aqua; 1 spray per nostril once/d AstraZeneca) Flunisolide (generic price) 2 spray per nostril, bid Nasalide (Ivax) Nasarel (Ivax) Fluticasone propionate 2 sprays per nostril once/d or (Flonase; GlaxoSmithKline) 1 spray per nostril, bid Mometasone furoate (Nasonex; 2 sprays per nostril once/d Schering) Triamcinolone acetonide 2 sprays each nostril once/d (Nasacort; Aventis) Nasacort AQ Oral [H.
In This One Year Study, Flunisolide HFA Did Not Suppress Growth or Bone Maturation at the Highest Approved Dose for Children with Mild Persistent Asthma