flumazenil


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flumazenil

 [floo-ma´zĕ-nil″]
a benzodiazepine agonist that competitively binds to receptor sites in the central nervous system; used to reverse the effects of benzodiazepines after sedation, general anesthesia, or overdose.

flu·ma·ze·nil

(flū'mā-zē-nil),
A benzodiazepine with antagonist properties at the benzodiazepine recognition site of the benzodiazepine-GABA-chloride channel complex. Used as a treatment for overdose with benzodiazepine-type central nervous system depressants, or for controlled reversal of anesthesia induced by such agents.

flumazenil

/flu·ma·ze·nil/ (floo-ma´zĕ-nil″) a benzodiazepine agonist used to reverse the effects of benzodiazepines after sedation, general anesthesia, or overdose.

flu·ma·ze·nil

(flū'mā-zē'nil)
Benzodiazepine with antagonist properties at the benzodiazepine recognition site of the benzodiazepine gamma-aminobutyric acid-chloride channel complex. Used to treat overdose with benzodiazepine-type central nervous system depressants or controlled reversal of anesthesia induced by such agents.

flumazenil

A drug that opposes the action of BENZODIAZEPINE drugs and can be used to reverse their sedating effect. A brand name is Anexate.

flu·ma·ze·nil

(flū'mā-zē'nil)
Benzodiazepine with antagonist properties used to treat overdose with benzodiazepine-type central nervous system depressants, or for controlled reversal of anesthesia induced by such agents.

flumazenil

(floo´mazənil´),
n brand name: Romazicon;
drug class: benzodiazepine receptor antagonist;
action: antagonizes actions of benziodiazepines on the central nervous system;
use: reversal of sedative effects of benzodiazepines.

flumazenil

a benzodiazepine antagonist.
References in periodicals archive ?
Neither flumazenil, 3-hydroxymethyl-beta-carboline (3-HMC), nor 5alpha-pregnane-3alpha, 20alpha-diol (5alpha-pregnanediol) affected thymol potentiation of the GABA response at alpha1beta3gamma2s receptors, providing evidence against actions at the benzodiazepine/beta-carboline or steroid sites.
Imidazole can be found in many other drugs such as dacarbazine, metronidazole, cimetidine, flumazenil, thyroliberin, methimazole, pilocarpine and etomidate which are used as antineoplastic antibiotic, antiulcerative, benzodiazepine antagonist, prohormone, antihyperthyroid, muscarinic receptor antagonist and hypnotic agents, respectively [8-11].
Flumazenil is an agent that binds to the same site as the benzodiazepines but without eliciting the downstream changes that lead to an increased affinity in receptors for GABA, resulting in flumazenil serving as a benzodiazepine antagonist.
Two medications with potential promise in open-label trials for methamphetamine dependence include vigabatrin, an anticonvulsant not approved for use in the United States, and a combination of flumazenil, gabapentin, and hydroxyzine.
If stopping benzodiazepines does not seem wise or possible, then the use of flumazenil just before ECT can temporarily reverse the effects of benzodiazepines.
Intravenous physostigrnine, flumazenil, or both may be used in severe cases.
He goes on to state that the PAs are neutralised by an existing drug called flumazenil which immediately clears up the pleasurable symptoms of drunkenness - slurred speech, uncontrollable legs, punching your hostess and falling into the Ming vases, that sort of thing.
Although he declined to reveal the treatment's contents, the firm's patent application indicates that Prometa includes intravenous administration of flumazenil or another selective chloride channel modulator, combined with varying doses of other drugs as well as nutritional and vitamin supplements.
Food and Drug Administration has granted tentative approval for an ANDA for Flumazenil Injection, 0.
These findings are consistent with an account of the GABA/benzodiazepine receptor complex in which both valproate and picrotoxin act at the chloride ion channel, while chlordiazepoxide acts at the benzodiazepine receptor and this is antagonized by flumazenil (in earlier publications this drug was referred to as Ro15-1788).
In: Hepatology: Flumazenil for Hepatic Encephalopathy Grade III and IVa in Patients With Cirrhosis: An Italian Multicenter Double-Blind, Placebo-Controlled, Cross-Over Study 1998: 374-378.