Fluid responsiveness was defined as a ≥15% increase in CO after fluid challenge when compared with baseline CO.
Of the 42 patients, 19 (45%) responded to fluid challenge, whereas 23 (55%) did not.
7 %) of the mini fluid challenges defined as non-responders.
This retrospective observational study used the ROC curve and gray zone approaches to examine the accuracy of cPDE in the evaluation of hemodilution response to mini fluid challenges with crystalloids in the mVLT protocol.
i] is the plasma dilution efficacy of the fluid challenge number i, [PD.
i] is arterio-capillary plasma dilution efficacy difference of the fluid challenge number i, a[PDE.
Four out of five patients with FTc less than 350 ms in our study responded to fluid challenge
, while all participants with FTc greater than 350 ms were non-responders.
These variables are clinically meaningful endpoints against which to define the clinical response to fluid challenge
Can changes in arterial pressure be used to detect changes in cardiac index during fluid challenge
in patients with septic shock?
where acGAP--arterio-capillary gap, aHb--arterial Hb, and SpHb--capillary Hb; i--identification number of an individual in the pool, 1--data point after first mini fluid challenge
Maternal hemodynamic parameters, including SBP, mean BP (MBP), HR, SpO [sub]2 , CO and SV, were recorded at the baseline (T1), following coloading with LR of 10 ml/kg (T2), 4 min following LR coloading (following first fluid challenge
test) (T3), 8 min following LR coloading (following second fluid challenge
test) (T4), stable blockade level obtained (thoracic level 5-3) (T5), immediate after delivery (T6), placental expulsion (T7), and discharge from operating room (T8).
Treatment for septic shock was standardized,[sup] including vasopressors (norepinephrine with epinephrine as a rescue therapy) to MAP, in addition to repeated fluid challenges
with crystalloids, natural albumin, and artificial colloids (hydroxyethyl starch solutions) to achieve a CVP of 8–12 mmHg, to maintain a MAP of at least 65 mmHg and to ensure that the urine output was at least 0.