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Ancobon, Ancotil (UK)
Pharmacologic class: Fluorinated pyrimidine analog
Therapeutic class: Antifungal
Pregnancy risk category C
Unclear. Thought to interfere with protein synthesis in cells of susceptible fungi after conversion to fluorouracil.
Capsules: 250 mg, 500 mg
⊘Indications and dosages
➣ Severe fungal infections caused by susceptible strains of Candida species (including septicemia, endocarditis, urinary tract infections [UTIs]), and pulmonary infections) and Cryptococcus species (including meningitis, pulmonary infections, and UTIs)
Adults: 50 to 150 mg/kg P.O. daily in four equally divided doses q 6 hours
• Renal impairment (glomerular filtration rate below 50 ml/minute)
• Hypersensitivity to drug or other antifungals
Use cautiously in:
• renal impairment, underlying hepatic disease, bone marrow depression
• pregnant or breastfeeding patients
• children (safety not established).
• Give capsules a few at a time over 15 minutes to minimize nausea and vomiting.
• Know that drug is rarely used alone. Expect to give another antifungal or amphotericin B concurrently.
CNS: headache, dizziness, confusion, hallucinations, vertigo, psychosis, ataxia, paresthesia, parkinsonism, peripheral neuropathy
CV: chest pain, cardiac arrest
EENT: hearing loss
GI: nausea, vomiting, diarrhea, dyspepsia, ulcerative colitis, abdominal discomfort, anorexia, duodenal ulcer, hemorrhage
GU: azotemia, crystalluria, renal failure
Hematologic: eosinophilia, anemia, leukopenia, aplastic anemia, thrombocytopenia, bone marrow depression, agranulocytosis
Metabolic: hypokalemia, hypoglycemia
Respiratory: dyspnea, respiratory arrest
Skin: rash, pruritus, urticaria, photosensitivity
Drug-drug.Amphotericin B: synergistic effects, increased risk of toxicity
Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, gamma-glutamyltransferase: increased levels
Glucose, granulocytes, hemoglobin, platelets, potassium, white blood cells: decreased levels
• Monitor kidney and liver function test results.
• Carefully monitor blood glucose level and hematologic test results.
☞ Assess for serious cardiovascular, renal, respiratory, and hematologic adverse reactions.
• Evaluate electrolyte levels, particularly potassium.
• Assess for signs and symptoms of bleeding.
• Advise patient to take capsules over 15-minute period to reduce GI upset.
☞ Instruct patient to immediately report unusual bleeding or bruising.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Instruct patient to minimize GI upset by eating frequent, small servings of food and drinking adequate fluids.
• Advise female patient to inform prescriber if she is pregnant or breastfeeding.
• Tell patient he'll undergo regular blood testing during therapy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.
flucytosine/flu·cy·to·sine/ (floo-si´to-sēn″) an antifungal used in the treatment of severe candidal and cryptococcal infections.
flucytosine5-FC, Ancobon Infectious disease An anti-fungal given with amphotericin B to ↓ emergence of resistant strains Adverse effects Liver damage. See AIDS.
flucytosineA drug used to treat fungus infections within the body. It can be taken by mouth and is effective against CRYPTOCOCCOSIS, chromomycosis and thrush (CANDIDIASIS). Side effects are minor.
n brand name: Ancobon;
drug class: antifungal;
action: converted to fluorouracil after entering fungi, which inhibits DNA and RNA synthesis;
uses: Candida infections.