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floxuridine/flox·uri·dine/ (floks-ūr´ĭ-dēn) a derivative of fluorouracil used as an antineoplastic.
an antineoplastic agent.
indications It is prescribed in the treatment of metastases to the liver from colon, stomach, and other GI cancers.
contraindications Bone marrow depression, infection, poor nutritional state, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects leading to drug discontinuation are severe depression of the bone marrow; acute GI disturbances, including nausea, vomiting, diarrhea, and stomatitis; and myocardial ischemia. Alopecia and dermatitis commonly occur.
floxuridineOncology An antimetabolic fluoropyrimidine, a metabolite of 5-FU. See 5-Fluorouracil.
a derivative of 5-fluorouracil used as an antiviral and antineoplastic agent; abbreviated FUDR.