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floxuridine

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
floxuridine /flox·uri·dine/ (floks-ūr´ĭ-dēn) a derivative of fluorouracil used as an antineoplastic.
floxuridine
[floksyoo͡r′ədēn]
an antineoplastic agent.
indications It is prescribed in the treatment of metastases to the liver from colon, stomach, and other GI cancers.
contraindications Bone marrow depression, infection, poor nutritional state, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects leading to drug discontinuation are severe depression of the bone marrow; acute GI disturbances, including nausea, vomiting, diarrhea, and stomatitis; and myocardial ischemia. Alopecia and dermatitis commonly occur.

floxuridine [floks-ūr´ĭ-dēn]
an antimetabolite, derived from fluorouracil and used as an antineoplastic agent by intra-arterial administration for treatment of liver metastases from gastrointestinal malignancies.

floxuridine
a derivative of 5-fluorouracil used as an antiviral and antineoplastic agent; abbreviated FUDR.

floxuridine
Oncology An antimetabolic fluoropyrimidine, a metabolite of 5-FU. See 5-Fluorouracil.


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The authors reported the quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis of tumour specimens from 94 patients who had advanced CRC and were treated with hepatic arterial infusion of floxuridine and dexamethasone in combination with systemic treatment with irinotecan after resection of liver metastases.
Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of a prospective randomized trial.
1, 1990 CANCER RESEARCH that two LDL-bound injected drugs -- methotrexate and floxuridine -- successfully dodged the body's natural clearance mechanisms to circulate at least six times longer in the blood of rats than did unbound drugs.
 
 
 
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