FLOT2

(redirected from flotillin-2)

FLOT2

A gene on chromosome 17q11-q12 that encodes a scaffolding protein present in caveolar membranes that participates in caveola and vesicle formation. It is expressed in the epidermis except the basal layer.
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Several authors use different markers for microvesicles like flotillin-2, selectins, integrins, metalloproteinases, and a high level of phosphatidylserine on the outer surface (Table 1).
Exosome Microvesicle, ectosome, shedding vesicles Size 40-100 nm 100-1000 nm Markers CD63, CD9, Alix, Anexin V, Flotillin-2, TSG 101, HSP 70 selectin, integrin, CD40 metalloproteinase Isolation Immunoprecipitation Ultracentrifugation method (ExoQuick[R]) (10,000-60,000 g) ultracentrifugation (100,000-200,000 g), ultracentrifugation with density gradient References 49,53 54 Apoptotic bodies Size 1000-5000 nm Markers Anexin V, DNA, histones Isolation No standardized protocol method References 55