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flocculation reaction

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flocculation reaction
n.
A precipitin test characterized by a flocculent precipitate of antigen and antibody. Also called flocculation test.


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When serum from a syphilis-infected individual is added to a suspension of cardiolipin antigen and charcoal, an antibody-antigen lattice forms, with the flocculation reaction visualized as clumping of the charcoal.
RELATED ARTICLE: Key Points * The prozone effect in syphilis testing refers to a false negative result seen in cases of high titers of antibodies interfering with the proper formation of the antigen-antibody lattice network needed to visualize a positive flocculation reaction.
 
 
 
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