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flecainide acetate |
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flecainide acetate, n brand name: Tambocor; drug class: antidysrhythmic (Class IC); action: decreases conduction in all parts of the heart with greatest effect on His-Purkinje system; uses: life-threatening ventricular dysrhythmias, sustained supraventricular tachycardia. flecainide acetate Warning - Hazardous drug! Tambocor Pharmacologic class: Cardiac benzamide local anesthetic Therapeutic class: Antiarrhythmic (class IC) Pregnancy risk category C FDA Boxed Warning• In patients with non-life-threatening ventricular arrhythmias who had recent myocardial infarctions and were receiving drug, excessive deaths and nonfatal cardiac arrest rates occurred. Don't give to patients without life-threatening ventricular arrhythmias. ActionInhibits fast sodium channels of myocardial cell membrane. Also slows conduction, shortens action potential, stops paroxysmal reentrant supraventricular tachycardia, and decreases conduction in accessory pathways in Wolff-Parkinson-White syndrome. AvailabilityTablets: 50 mg, 100 mg, 150 mg ⊘Indications and dosages ➣ Supraventricular tachyarrhythmias (including paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation or flutter) Adults: Initially, 50 mg P.O. q 12 hours, increased by 50 mg b.i.d. q 4 days until desired response occurs or maximum daily dosage of 300 mg is reached. ➣ Sustained, life-threatening ventricular tachycardia Adults: Initially, 100 mg P.O. q 12 hours, increased by 50 mg b.i.d. q 4 days until desired response occurs or maximum daily dosage of 400 mg is reached. Dosage adjustment• Heart failure Off-label uses• Ventricular arrhythmias Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Initiate therapy only in hospital setting with trained personnel and continuous ECG monitoring.
Adverse reactionsCNS: dizziness, anxiety, fatigue, headache, depression, malaise, tremor, weakness, hypoesthesia, paresthesia CV: chest pain, palpitations, second- or third-degree heart block, heart failure, new or worsening arrhythmias EENT: blurred vision, visual disturbances, corneal deposits GI: nausea, vomiting, constipation, abdominal pain, dyspepsia, anorexia Hepatic: hepatitis Respiratory: dyspnea Skin: rash, diaphoresis Other: edema, fever InteractionsDrug-drug. Acidifying drugs: increased renal elimination, decreased efficacy of flecainide (with urine pH below 5) Alkalizing drugs: increased flecainide blood level, possible toxicity Amiodarone: doubling of flecainide blood level Beta-adrenergic blockers: increased blood levels of both drugs Beta-adrenergic blockers, disopyramide, verapamil: additive myocardial depressant effect Digoxin: 15% to 25% increase in digoxin blood level Other antiarrhythmics (including calcium channel blockers): increased risk of arrhythmias Drug-diagnostic tests. Alkaline phosphatase: increased level (with prolonged therapy) Drug-food. Foods that decrease urine pH below 5 (such as acidic juices): increased renal elimination and possibly decreased efficacy of drug Foods that increase urine pH above 7 (as in strict vegetarian diets): increased drug blood level Drug-behaviors. Smoking: increased plasma clearance and decreased efficacy of drug Patient monitoring☞ Monitor ECG for worsening arrhythmias. Patient teaching☞ Instruct patient to immediately report cardiac or respiratory symptoms, unusual tiredness, or yellowing of skin or eyes. |
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NYSE: MYL) announced today that it has reached an agreement with 3M Pharmaceuticals for an exclusive supply and distribution agreement to sell Flecainide Acetate Tablets in bottles of 100 of the 50 mg, 100 mg and 150 mg strengths. |
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