flavocoxid

flavocoxid

(fla-vo-cox-id) ,

Limbrel

(trade name)

Classification

Therapeutic: nonopioid analgesics
Pharmacologic: flavanoids
Pregnancy Category: UK

Indications

Dietary management of osteoarthritis; considered to be a medical food product.

Action

Anti-inflammatory and analgesic properties related to inhibition of prostaglandin synthesis by inhibiting cyclo-oxygenase (not COX-2 selective) and other mediators of inflammation.

Therapeutic effects

Decreased pain/inflammation associated with osteoarthritis, with improved mobility.

Pharmacokinetics

Absorption: Some intestinal conversion prior to absorption, remainder unknown.
Distribution: Unknown.
Metabolism and Excretion: Mostly metabolized by the liver.
Half-life: Unknown.

Time/action profile (analgesic effect)

ROUTEONSETPEAKDURATION
POwithin 1–2 hrunknown12 hr

Contraindications/Precautions

Contraindicated in: Hypersensitivity; Obstetric / Lactation / Pediatric: Not recommended.
Use Cautiously in: History of GI bleeding.

Adverse Reactions/Side Effects

Cardiovascular

  • ↑ BP
  • ↑ in varicose veins

Gastrointestinal

  • GI upset

Dermatologic

  • psoriasis

Interactions

Drug-Drug interaction

None noted.

Route/Dosage

Oral (Adults) 250 mg every 12 hr (up to 250 mg three times daily has been used).

Availability

Capsules: 250 mg

Nursing implications

Nursing assessment

  • Assess pain (note type, location, and intensity), range of motion, degree of swelling, and stiffness in affected joints before and periodically during therapy.

Potential Nursing Diagnoses

Chronic pain (Indications)

Implementation

  • Oral: Administer flavocoxid twice daily.

Patient/Family Teaching

  • Instruct patient to take flavocoxid as directed. Do not increase does without consulting health care professional.

Evaluation/Desired Outcomes

  • Decrease in pain and stiffness, and improved mobility in patients with osteoarthritis.

flavocoxid

an oral nutritional supplement.
indication This drug is used for dietary management of osteoarthritis.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Adverse effects of this drug include hypertension, increase in varicose veins, psoriasis, and fluid accumulation in the knees.
Mentioned in ?
References in periodicals archive ?
Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.
One such extract with strong supporting human outcome studies, flavocoxid, will be discussed in this article with emphasis on its safety profile and balanced action across a multitude of inflammatory pathways.
Flavocoxid is a specially manufactured and extensively studied natural food-based product composed of enriched plant extracts from two botan icals, Scutellaria baicalensis and Acacia catechu.
These mechanisms make flavocoxid an interesting therapeutic alternative to nonsteroidal anti-inflammatory drugs.
Because it is classified as a medical food, flavocoxid was marketed beginning in 2004 in the absence of any published randomized trial.
Glucosamine, chondroitin and flavocoxid can affect clotting agents;
Limbrel contains flavocoxid, a proprietary composition of natural flavonoid ingredients from the plant sources of Scutellaria baicalensis and Acacia catechu that meet the FDA strict safety standard of Generally Recognized As Safe (GRAS).
A proprietary mixture of flavonoids (baicalin and catechin) known as flavocoxid (Limbrel) was tested against naproxen, a conventional non-steroidal anti-inflammatory drug for the management of moderate osteoarthritis (OA) of the knees.
Flavocoxid is comprised primarily of flavonoids, such as baicalin and catechin, and Limbrel provides levels of these flavonoids to meet the distinctive nutritional requirements of people with OA and cannot be obtained through simply changing the diet.
Limbrel contains flavocoxid, a patent-pending blend of natural ingredients, comprised primarily of the concentrated flavonoids baicalin and catechin, which are recognized for their anti-inflammatory and antioxidant properties.
Safety, efficacy and acceptability of flavocoxid (Limbrel[TM]) compared with naproxen in subjects with osteoarthritis of the knee: a pilot study.
It contains flavocoxid, a patent-pending combination of natural ingredients comprised primarily of concentrated flavonoids baicalin and catechin.